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12-Lipoxygenase (platelet-type, mouse recombinant)

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    12-<wbr/>Lipoxygenase (platelet-<wbr/>type, mouse recombinant)
  • 12-<wbr/>Lipoxygenase (platelet-<wbr/>type, mouse recombinant)
Cat No: 10341
Proteins - Enzymes
Cayman
€396.00
Price is excluding VAT and does not include packaging neither shipping

12-Lipoxygenase (12-LO) catalyzes the formation of 12-HpETE from arachidonic acid.{3606} There are two main types of 12-LO, platelet-type and leukocyte-type, which share only 60% identity at the amino acid level and strongly differ in substrate specif...

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: 25 µg

This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Pharma only in Europe
Correlated keywords:
  • 12 LOs 12 LOXs 12 lipoxygenase P 12LO ALOX arachidonic acids platelet-type leukocyte-type epidermal-type 12-HETE 12 HETE 12-HpETE 12 HpETE 15-HETE 15 HETE 15-HpETE 15 HpETE active
Product Overview:
12-Lipoxygenase (12-LO) catalyzes the formation of 12-HpETE from arachidonic acid.{3606} There are two main types of 12-LO, platelet-type and leukocyte-type, which share only 60% identity at the amino acid level and strongly differ in substrate specificity and enzyme kinetics.{17945} Leukocyte-type 12-LO has the ability to also produce 15-HpETE, however, platelet-type predominately forms 12-HpETE.{17945} Epidermal-type 12(S)- and 12(R)-LO enzymes have also been characterized, which catalyze the synthesis of their respective stereospecific 12-HETE products.{17945,13657}
Size 25 µg
Shipping dry ice
Stability Store at -80 degrees; shelf life 365 days
Formulation 50 mM sodium phosphate pH 7.2, 100 mM sodium chloride, 20 µM FeCl2, and 30% glycerol
Purity ≥80% estimated by SDS-PAGE
Custom Code 3507.90
UNSPSC code 12352204

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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