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Prostaglandin A3

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    Prostaglandin A<sub>3</sub>
  • Prostaglandin A<sub>3</sub>
Cat No: 10310
Biochemicals - Lipids
Cayman

Cyclooxygenase metabolism of EPA to produce Prostaglandin E3 (PGE3) has been reported in biosynthetic preparations of ovine seminal vesicles{963} and in the ocular tissues of primates.{1144} Prostaglandin A3 (PGA3) is an expected non-enzymatic dehydrat...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 9-oxo-15S-hydroxy-prosta-5Z,10,13E,17Z-tetraen-1-oic acid
Correlated keywords:
  • PGA3 omega-3 prostaglandins .omega.-3 w-3
Product Overview:
Cyclooxygenase metabolism of EPA to produce Prostaglandin E3 (PGE3) has been reported in biosynthetic preparations of ovine seminal vesicles{963} and in the ocular tissues of primates.{1144} Prostaglandin A3 (PGA3) is an expected non-enzymatic dehydration product of this PGE3. PGA3 exhibits good affinity for the canine EP2 and EP4 receptors with IC50 values of 120 nM and 20 nM, respectively, in a radioligand binding assay.{11147,11148} PGA3 has weak affinity for human PPARγ, with a Ki value of 188 µM.{11138}
Size 25 µg
Shipping dry ice
CAS Number 36614-31-0
Molecular Formula C20H28O4
SMILES O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)C/C=C\CC)C=C1
Molecular Weight 332,4
Formulation A solution in methyl acetate
Purity ≥98%
Custom Code 2937.50
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

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