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Nrf2 (C-Term) Polyclonal Antibody

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    Nrf2 (C-<wbr/>Term) Polyclonal Antibody
  • Nrf2 (C-<wbr/>Term) Polyclonal Antibody
Cat No: 10214
Antibodies - Polyclonal Antibodies
Cayman
€342.00
Price is excluding VAT and does not include packaging neither shipping

This C-terminal Nrf2 polyclonal antibody preferentially detects polyubiquitinated Nrf2 at 90 kDa. Nrf2 is a transcription factor that forms a heterodimer with a small Maf protein and binds to the antioxidant response element in the upstream promoter r...

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: 1 ea

This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Pharma only in Europe
Correlated keywords:
  • transcription factors heterodimer Maf antioxidative Kelch ECH CUL3 Keap-1 ubiquination inflammatory NRF2 Nrf-2 NFE2-related factor 2 c-terminal cterm HEBP-1 ferroptosis
Product Overview:
This C-terminal Nrf2 polyclonal antibody preferentially detects polyubiquitinated Nrf2 at 90 kDa. Nrf2 is a transcription factor that forms a heterodimer with a small Maf protein and binds to the antioxidant response element in the upstream promoter region of many antioxidative genes.{22024} Under normal, unstressed conditions, Nrf2 is sequestered in the cytoplasm where it is bound to and ubiquitinated by kelch-like ECH-associated protein 1 (Keap1) and cullin 3.{22021} Certain inflammatory, environmental, or oxidative stressors disrupt Keap1 binding and prevent ubiquitination. This leads to a buildup of Nrf2 in the cytoplasm, and subsequent translocation into the nucleus.{22023} Cayman’s Nrf2 (C-Term) Polyclonal Antibody can be used for flow cytometry, immunofluorescence, and Western blot applications. The antibody recognizes Nrf2 at 90 kDa from human, mouse, and rat samples.
Size 1 ea
Shipping dry ice
Stability Store at -20 degrees; shelf life 365 days
Host Rabbit
Antigen Synthetic peptide from the C-terminal region of human protein Nrf2
Application(s)

FC, ICC, and WB

Formulation 500 µl of peptide affinity-purified antibody
Custom Code 3822.00
UNSPSC code 12352203

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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