APF - C26H17NO5 - Bertin Bioreagent

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APF

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Cat No: 10157

APF is an aromatic amino-fluorescein derivative and fluorescent probe for highly reactive radicals.{11242} It has low intrinsic fluorescence, however, upon oxidation by hydroxyl radical, hypochlorite ion, and certain peroxidase intermediates, it is co...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-[6-(4-aminophenoxy)-3-oxo-3H-xanthen-9-yl]-benzoic acid

Correlated keywords:

fluorescence oxidants oxidation radicals gerontology free fluorescent biological hydrogen peroxide H2O2 NO nitric oxides DCDHF dichlorohydrofluorescein

Product Overview:
APF is an aromatic amino-fluorescein derivative and fluorescent probe for highly reactive radicals.{11242} It has low intrinsic fluorescence, however, upon oxidation by hydroxyl radical, hypochlorite ion, and certain peroxidase intermediates, it is converted to the highly fluorescent molecule fluorescein, facilitating the detection of highly reactive biological radicals.{11242} APF is not oxidized by nitric oxide (NO), hydrogen peroxide (H2O2), or other oxidants. Fluorescein displays excitation/emission maxima of 490/515 nm, respectively.

Size	500 µg
Shipping	dry ice
CAS Number	359010-70-1
Molecular Formula	C₂₆H₁₇NO₅
SMILES	Nc1ccc(cc1)Oc1ccc2c(c1)Oc1cc(O)ccc1C12OC(=O)c2ccccc12
Molecular Weight	423,4
Formulation	A solution in methyl acetate
Purity	≥98%
Custom Code	2918.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.