Cefepime (hydrochloride hydrate)

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Cat No: 23633

Cefepime is a broad-spectrum cephalosporin antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria.{38779,38780} It inhibits the growth of some clinical isolates of Corynebacterium, Streptococcus, and Staphylococcus (MIC90s = 0...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-pyrrolidinium, monochloride, monohydrochloride, monohydrate

Correlated keywords:

88376-58-3 647035-01-6 anti-biotic Proteus Escherichia Cepimax Cepimex Axepim BMY28142 BMY-28142

Product Overview:
Cefepime is a broad-spectrum cephalosporin antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria.{38779,38780} It inhibits the growth of some clinical isolates of Corynebacterium, Streptococcus, and Staphylococcus (MIC90s = 0.03-8 μg/ml), but does not inhibit the growth of methicillin-resistant S. aureus (MRSA) or S. haemolyticus (MIC50s = >128 μg/ml).{38779} Cefepime inhibits the growth of some Citrobacter, Enterobacter, Klebsiella, Salmonella, Serratia, Shigella, and enteric bacilli species in addition to P. mirabilis and E. coli clinical isolates (MIC90s = ≤0.12-2 μg/ml).{38780} It also inhibits the growth of E. coli and Klebsiella strains that produce extended-spectrum β-lactamase (ESBL; MIC90s = 4 and 8 μg/mL, respectively) and of indole-positive Proteae (MIC90 = 0.25 μg/ml). Cefepime inhibits the growth of pneumococci strains (MICs = 0.5-2 mg/l) in vitro and in vivo in a mouse model of peritonitis (ED50s = 0.6-1.14 mg/kg).{38781} Formulations containing cefepime have been used in the treatment of a variety of bacterial infections.

Size	250 mg
Shipping	dry ice
CAS Number	123171-59-5
Molecular Formula	C₁₉H₂₅N₆O₅S₂ • Cl [HCl] [H₂O]
SMILES	O=C(O)C1=C(C[N+]2(C)CCCC2)CS[C@@]([C@@H]3NC(/C(C4=CSC(N)=N4)=N\OC)=O)([H])N1C3=O.[Cl-].Cl.O
Molecular Weight	571,5
Formulation	A crystalline solid
Purity	≥90%
Custom Code	2930.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.