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8-iso Prostaglandin F2?-d4

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    8-<wbr/><em>iso</em> Prostaglandin F<sub>2?</sub>-<wbr/>d<sub>4</sub>
  • 8-<wbr/><em>iso</em> Prostaglandin F<sub>2?</sub>-<wbr/>d<sub>4</sub>
Cat No: 316350
Biochemicals - Isotopically Labeled Standards

8-iso PGF2α-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 8-iso PGF2α by GC- or LC-mass spectrometry. 8-iso Prostaglandin F2α (8-iso PGF2α) is an isoprostan...


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Territorial Availability: Available through Bertin Technologies only in France
  • 9?,11?,15S-trihydroxy-(8?)-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 acid
Correlated keywords:
  • GC/MS deuterium isotopes 8-isoprostanes 8-epi-PGF2.alpha.-d4 8-epi-PGF2alpha-d4 8-iso-PGF2.alpha.-d4 8-iso-PGF2alpha-d4 internal standards prostaglandins mass spectrometry LC/MS GC-MS LC-MS deuterated 8-iso-PGF2a-d4 8-epi-PGF2a-d4 ipf2a neurochemistry 316351
Product Overview:
8-iso PGF2α-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 8-iso PGF2α by GC- or LC-mass spectrometry. 8-iso Prostaglandin F2α (8-iso PGF2α) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.{320,371,855} It circulates in human plasma in two distinct forms - esterified in LDL phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine.{320,371} 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle.{6640} Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-46619 (10−6 M) and I-BOP (3 x 10−7 M) with IC50 values of 1.6 x 10−6 M and 1.8 x 10−6 M, respectively.{855}
Size 25 µg
Shipping dry ice
CAS Number 211105-40-7
Molecular Formula C20H30D4O5
SMILES O[C@@H]1[C@@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](/C=C/[C@H](O)CCCCC)[C@H](O)C1
Molecular Weight 358,5
Formulation A solution in methyl acetate
Purity ≥99% deuterated forms (d1-d4)
Custom Code 3822.19
UNSPSC code 12352100

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