Confirm delete?

Bertin Bioreagent
logo
All categories
Contact Us
You are here :

8-iso Prostaglandin F-d4

  • Zoom
    8-<wbr/><em>iso</em> Prostaglandin F<sub>2α</sub>-<wbr/>d<sub>4</sub>
  • 8-<wbr/><em>iso</em> Prostaglandin F<sub>2α</sub>-<wbr/>d<sub>4</sub>
Cat No: 316350
Biochemicals - Isotopically Labeled Standards
Cayman
€177.00
Price is excluding VAT and does not include packaging neither shipping

8-iso PGF2α-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 8-iso PGF2α by GC- or LC-mass spectrometry. 8-iso Prostaglandin F2α (8-iso PGF2α) is an isoprostan...

More

This product can only be bought through Cayman Chemical. Please contact us.

- +
Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 9α,11α,15S-trihydroxy-(8β)-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 acid
Correlated keywords:
  • GC/MS deuterium isotopes 8-isoprostanes 8-epi-PGF2.alpha.-d4 8-epi-PGF2alpha-d4 8-iso-PGF2.alpha.-d4 8-iso-PGF2alpha-d4 internal standards prostaglandins mass spectrometry LC/MS GC-MS LC-MS deuterated 8-iso-PGF2a-d4 8-epi-PGF2a-d4 ipf2a neurochemistry 316351
Product Overview:
8-iso PGF2α-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 8-iso PGF2α by GC- or LC-mass spectrometry. 8-iso Prostaglandin F2α (8-iso PGF2α) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.{320,371,855} It circulates in human plasma in two distinct forms - esterified in LDL phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine.{320,371} 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle.{6640} Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-46619 (10−6 M) and I-BOP (3 x 10−7 M) with IC50 values of 1.6 x 10−6 M and 1.8 x 10−6 M, respectively.{855}
Size 25 µg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 211105-40-7
Molecular Formula C20H30D4O5
SMILES O[C@@H]1[C@@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](/C=C/[C@H](O)CCCCC)[C@H](O)C1
Molecular Weight 358,5
Formulation A solution in methyl acetate
Purity ≥99% deuterated forms (d1-d4)
Custom Code 2937.50
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

/ We also advise you

Cross selling for this product : 8-<wbr/><em>iso</em> Prostaglandin F<sub>2α</sub>-<wbr/>d<sub>4</sub> There are 4 products.

Search