EOS-d9 (d18:1-d9/32:0/18:2)

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EOS-d₉ (d18:1-d₉/32:0/18:2)

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Cat No: 24423

Biochemicals - Isotopically Labeled Standards

EOS-d9 (d18:1-d9/32:0/18:2) is intended for use as an internal standard for the quantification of EOS (Item No. 22442) by GC- or LC-MS. EOS is a ceramide found in the outer layer of the epidermis in mammals.{34500} It is comprised of an ω-hydroxy very...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

32-(((2S,3R,E)-1,3-dihydroxyoctadec-4-en-2-yl-15,15,16,16,17,17,18,18,18-d9)amino)-32-oxodotriacontyl (9Z,12Z)-octadeca-9,12-dienoate

Correlated keywords:

deuterated deuterium C-28 eLOX-3 VLCFA FA C36 12RLO

Product Overview:
EOS-d9 (d18:1-d9/32:0/18:2) is intended for use as an internal standard for the quantification of EOS (Item No. 22442) by GC- or LC-MS. EOS is a ceramide found in the outer layer of the epidermis in mammals.{34500} It is comprised of an ω-hydroxy very long-chain fatty acid (C28-36) esterified to the essential fatty acid linoleic acid (Item No. 90150) and glucosylated to sphingosine. The consecutive regio- and stereospecific oxygenation of the linoleate portion of EOS by 12(R)-lipoxygenase (12(R)-LO) and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss. Following oxygenation, the oxidized linoleate is hydrolyzed, leaving the ω-hydroxy end of the very long-chain fatty acid to covalently bind the protein layer, forming the corneocyte lipid envelope and sealing the gap between the extracellular lipid lamellae and the cornified cell envelope of the corneocyte. [Matreya, LLC. Catalog No. 2208]

Size	1 mg
Shipping	dry ice
Molecular Formula	C₆₈H₁₂₀D₉NO₅
SMILES	OC[C@H](NC(CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O)[C@H](O)/C=C/CCCCCCCCCC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]
Molecular Weight	1049,8
Formulation	A solid
Purity	≥99% deuterated forms (d1-d9)
Custom Code	3822.19
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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