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Prostaglandin D Synthase (hematopoietic-type; human, recombinant)

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    Prostaglandin D Synthase (hemato<wbr/>poietic-type; human, recombinant)
  • Prostaglandin D Synthase (hemato<wbr/>poietic-type; human, recombinant)
Cat No: 10006593
Proteins - Enzymes

Prostaglandin D synthase (PGDS) is a glutathione-dependent enzyme and member of the sigma class of glutathione-S-transferases (GSTs) that catalyzes the conversion of PGH2 (Item No. 17020) to PGD2 (Item No. 12010), an eicosanoid that has numerous biolo...

: 100 µg

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Territorial Availability: Available through Bertin Technologies only in France
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Product Overview:
Prostaglandin D synthase (PGDS) is a glutathione-dependent enzyme and member of the sigma class of glutathione-S-transferases (GSTs) that catalyzes the conversion of PGH2 (Item No. 17020) to PGD2 (Item No. 12010), an eicosanoid that has numerous biological functions, including vasorelaxation, recruitment of inflammatory cells, and inhibition of platelet aggregation.{13033,24779,57198} There are two types of PGDS: lipocalin PGDS (L-PGDS; Item Nos. 10006788
10010548) and hematopoietic PGDS (H-PGDS; Item Nos. 10006593
10004347).{57198} H-PGDS is found in peripheral tissues and immune cells, including Th2 cells, antigen-presenting cells, mast cells, megakaryocytes, and eosinophils, where it is localized to the cytosol.{24779} H-PGDS activity is increased by a variety of stimuli, including LPS, anti-IgE antibodies, phorbol 12-myristate 13-acetate (TPA; Item No. 10008014), ionomycin (Item No. 10004974), and inflammatory cytokines such as IL-13, IL-3, or IL-4.{57198} siRNA silencing of Hpgds decreases LPS-induced production of PGD2 in mouse bone marrow-derived macrophages (BMDMs).{25435} Transgenic overexpression of HPGDS in mice increases croton oil-induced ear swelling and PGD2 production, and genome-wide deletion of Hpgds exacerbates hypotension and vascular permeability in a mouse model of anaphylaxis.{57266,57267} H-PGDS protein levels are increased in the nasal mucosa of patients with allergic rhinitis, and HPGDS SNPs have been found in individuals with asthma.{57198,13033} Cayman's Prostaglandin D Synthase (hematopoietic-type; human, recombinant) can be used for enzyme activity assays.
Size 100 µg
Shipping dry ice
Formulation 50 mM sodium phosphate, pH 7.2, containing 20% glycerol, 100 mM sodium chloride, 1 mM DTT, and 0.5 mM EDTA
Purity ≥95% estimated by SDS-PAGE
Custom Code 3507.90
UNSPSC code 12352204

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