Anti-Carbamylation (Homocitrulli

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Anti-Carbamylation (Homocitrulline) Monoclonal Antibody

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Cat No: 23203

Carbamylation is a non-enzymatic and irreversible post-translational protein modification whereby cyanate/isocyanic acid adds a carbamoyl group to the ε-amino of lysine side chains, converting lysine to the non-standard amino acid homocitrulline.{5304...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

nonenzymatic e-carbamyl myeloperoxidase CKD RA PTM anticarbamylation

Product Overview:
Carbamylation is a non-enzymatic and irreversible post-translational protein modification whereby cyanate/isocyanic acid adds a carbamoyl group to the ε-amino of lysine side chains, converting lysine to the non-standard amino acid homocitrulline.{53049,53050} Cyanate is formed primarily from the breakdown of urea but can also be formed from the oxidation of thiocyanate by myeloperoxidase in the presence of hydrogen peroxide at sites of inflammation, such as atherosclerotic tissues.{53049,53050,32815} LDL can be carbamylated and has atherogenic properties, disrupting LDL receptor binding and increasing vascular smooth muscle cell proliferation and endothelial cell death.{32815,53051} Protein carbamylation and carbamylated LDL levels are increased in the plasma of patients with disorders resulting in high levels of urea, such as chronic and end-stage renal diseases.{53050,53051} Furthermore, the levels of plasma protein-bound homocitrulline positively correlate with the frequency of, and mortality from, major adverse cardiac events and predict cardiovascular disease risk.{32815} Carbamylated proteins can also induce an immune response leading to the production of anti-homocitrulline autoantibodies, which have been found at higher levels in individuals with rheumatoid arthritis and are positively associated with the degree of joint damage.{34536} Cayman’s Anti-Carbamylation (Homocitrulline) Monoclonal Antibody can be used for ELISA, immunoprecipitation (IP), and Western blot (WB) applications. The antibody recognizes carbamylated proteins and does not detect the unmodified or citrullinated counterparts.

Size	100 µg
Shipping	dry ice
Host	Mouse
Antigen	Carbamylated protein
Clone	1C6
Isotype	IgG1
Application(s)	ELISA, IP, WB
Formulation	100 µg protein G-purified antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.