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Anti-Carbamylation (Homocitrulline) Monoclonal Antibody

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    Anti-<wbr/>Carbamylation (Homo<wbr/>citrulline) Monoclonal Antibody
  • Anti-<wbr/>Carbamylation (Homo<wbr/>citrulline) Monoclonal Antibody
Cat No: 23203
Antibodies - Monoclonal Antibodies
Cayman
€434.00
Price is excluding VAT and does not include packaging neither shipping

Carbamylation is a non-enzymatic and irreversible post-translational modification whereby cyanate reacts with lysine residues within polypeptide chains to generate ε-carbamyl-lysine (homocitrulline).{34533} Cyanate originates from the decomposition of...

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: 100 µg

This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Correlated keywords:
  • nonenzymatic e-carbamyl myeloperoxidase CKD RA PTM anticarbamylation
Product Overview:
Carbamylation is a non-enzymatic and irreversible post-translational modification whereby cyanate reacts with lysine residues within polypeptide chains to generate ε-carbamyl-lysine (homocitrulline).{34533} Cyanate originates from the decomposition of urea and exists in equilibrium with its reactive form isocyanic acid.{34532} Neutrophil-derived MPO mediates the conversion of thiocyanate to isocyanate at sites of inflammation.{34533,34534} Increased levels of urea associated with chronic kidney disease result in elevated cyanate concentrations and a higher potential for carbamylated proteins.{34535} The presence of carbamylated proteins has been associated with rheumatoid arthritis.{34536} Homocitrulline residues are structurally similar to citrulline, the presence of an additional methylene group on homocitrulline being the only difference. Peptidylarginine deiminase (PAD)-catalyzed formation of citrulline residues on proteins and peptides can indicate many of the same disease states as the presence of homocitrulline residues. The ability to differentiate between citrullinated and carbamylated proteins has been difficult using traditional techniques. Cayman’s Anti-Carbamylation (Homocitrulline) Monoclonal Antibody specifically detects carbamylated proteins and does not detect the unmodified or citrullinated counterparts.
Size 100 µg
Shipping dry ice
Stability Store at -20 degrees; shelf life 365 days
Host Mouse
Antigen Carbamylated protein
Clone 1C6
Isotype IgG1
Application(s)

ELISA, IP, WB

Formulation 100 µg protein G-purified antibody
Custom Code 3822.00
UNSPSC code 12352203

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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