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  • (±)12(13)-<wbr/>DiHOME
Cat No: 10009832
Biochemicals - Lipids
Price is excluding VAT and does not include packaging neither shipping

A metabolite of (±)12(13)-EpOME
(±)12(13)-DiHOME is the diol resulting from the soluble epoxide hydrolase opening of (±)12(13)-EpOME (Item No. 52450). The mixture of the methyl ester of this diol and the 9,10 isomer are more cytotoxic than the methyl ...


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Territorial Availability: Available through Bertin Technologies only in Europe
  • (±)12,13-dihydroxy-9Z-octadecenoic acid
  • Isoleukotoxin diol
Correlated keywords:
  • epoxides
  • epoxygenase
  • leukotoxin
  • cytochrome
  • P450
  • CYP450
  • sEH
  • soluble
Show more...
Product Overview:
A metabolite of (±)12(13)-EpOME
(±)12(13)-DiHOME is the diol resulting from the soluble epoxide hydrolase opening of (±)12(13)-EpOME (Item No. 52450). The mixture of the methyl ester of this diol and the 9,10 isomer are more cytotoxic than the methyl ester epoxides in renal proximal tubular cells. However, in renal cortical mitochondria, the conversion of the epoxide to (±)12(13)-DiHOME appears to be part of the detoxification pathway that prevents mitochondrial dysfunction. This diol and the 9,10 isomer can be glucuronidated by human liver and intestinal microsomes as well as recombinant UGT2B7 through a hydroxyl group. High levels of LA-diol glucuronides have been found in the urine of humans with peroxisomal diseases. A mixture of the diols stimulates breast cancer cell proliferation in vitro and disrupts reproductive function in rats at relatively low concentrations.
Size 25 µg
Shipping wet ice
Stability Store at -20 degrees; shelf life 365 days maximum after production
CAS Number 263399-35-5
Molecular Formula C18H34O4
Molecular Weight 314.5
Formulation A solution in methyl acetate
Purity ≥98%
Custom Code 2916196000
UNSPSC code 12352100
UN Number UN1231

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

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Cross selling for this product : (±)12(13)-<wbr/>DiHOME There are 3 products.