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Thio-TEPA

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    Thio-TEPA
  • Thio-TEPA
Cat No: 23745
Biochemicals - More Biochemicals
Cayman
€51.00
Price is excluding VAT and does not include packaging neither shipping

An alkylating agent with anticancer activity (IC50 = 1.5 ?M against P388 murine leukemia cells); alkylates DNA and inhibits thymidine incorporation (IC50 = 2 ?M) inducing irreversible DNA damage; crosslinks guanine nucleotides and induces cell cycle ar...

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 1,1',1''-phosphinothioylidynetris-aziridine
  • NCI C01649
  • NSC 6396
  • Triethylenethiophosphoramide
Correlated keywords:
  • 639-23-6
  • 85177-92-0
  • 1631739-26-8
  • AI
  • 3-24916
  • AI324916
  • CBC-806495
  • CBC806495
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Product Overview:
An alkylating agent with anticancer activity (IC50 = 1.5 ?M against P388 murine leukemia cells); alkylates DNA and inhibits thymidine incorporation (IC50 = 2 ?M) inducing irreversible DNA damage; crosslinks guanine nucleotides and induces cell cycle arrest via the formation of interstrand cross-links in L1210 and MCF-7 cancer cells in vitro; reduces the number of pulmonary metastases in mice following subcutaneous injection of melanoma cells; decreases the number of postoperative lung metastases when administered at a dose of 10 mg/kg after surgical removal of an S-91 melanoma tumor established via intramuscular injection in mice
Thio-TEPA is an alkylating agent with anticancer activity (IC50 = 1.5 ?M against P388 murine leukemia cells). It alkylates DNA and inhibits thymidine incorporation (IC50 = 2 ?M) inducing irreversible DNA damage. Thio-TEPA crosslinks guanine nucleotides and induces cell cycle arrest via the formation of interstrand crosslinks in L1210 and MCF-7 cancer cells in vitro. In vivo, thio-TEPA reduces the number of pulmonary metastases in mice following subcutaneous injection of melanoma cells. It also decreases the number of postoperative lung metastases when administered at a dose of 10 mg/kg after surgical removal of an S-91 melanoma tumor established via intramuscular injection in mice.
Size 250 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days maximum after production
CAS Number 52-24-4
Molecular Formula C6H12N3PS
SMILES S=P(N1CC1)(N2CC2)N3CC3
Molecular Weight 189.2
Formulation A solid
Purity ≥98%
Custom Code 2930909165
UNSPSC code 12352100
UN Number UN2811

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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