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Digoxin

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    Digoxin
  • Digoxin
Cat No: 22266
Biochemicals - Ion Channel Modulation
Cayman

Digoxin is a cardiac glycoside and metabolite of digitoxin that binds to and inhibits the Na+/K+-ATPase in cardiac tissues in an ATP- and Mg2+-dependent manner.{38192} This inhibition results in loss of the transmembrane Na+ gradient, which decreases ...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (3?,5?,12?)-3-[(O-2,6-dideoxy-?-D-ribo-hexopyranosyl-(1?4)-O-2,6-dideoxy-?-D-ribo-hexopyranosyl-(1?4)-2,6-dideoxy-?-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-card-20(22)-enolide
Correlated keywords:
  • 36-35-1 8001-36-3 8001-37-4 8001-52-3 11000-95-6 39366-41-1 82476-60-6 NSC95100 12b-Hydroxydigitoxin Cardigox Cardiogoxin Cardioxin Cardixin Cardoxin Chloroformic digitalin Coragoxine Cordioxil Davoxin Digacin Digicor Digitek Digomal Digon Digosin Nativelle Digoxine Dilanacin Dixina Dokim Dynamos Eudigox Fargoxin Grexin Homolle's digitalin Lanacordin Lanacrist Lanicor Lanikor Lanocardin Lanorale Lanoxicaps Lanoxin-PG Lenoxicaps Lenoxin Longdigox Mapluxin Natigoxin NeoDioxanin Novodigal-Amp Purgoxin Rougoxin Stillacor Toloxin Vanoxin adenosine triphosphatase
Product Overview:
Digoxin is a cardiac glycoside and metabolite of digitoxin that binds to and inhibits the Na+/K+-ATPase in cardiac tissues in an ATP- and Mg2+-dependent manner.{38192} This inhibition results in loss of the transmembrane Na+ gradient, which decreases activity of the Na+/Ca2+ exchanger, increasing intracellular Ca2+ levels, inotropy, and cardiac force.{38193} It increases activity of mitochondrial ATPase and actomyosin ATPase in rat hearts, which is directly correlated with increased myofibrillar contractile strength.{38194} In vivo, digoxin also decreases right atrial pressure and increases cardiac output in a canine model of congestive heart failure produced by pulmonary artery constriction.{38195} Formulations containing digoxin have been used to treat atrial fibrillation.{38196}
Size 250 mg
Shipping dry ice
CAS Number 20830-75-5
Molecular Formula C41H64O14
SMILES C[C@@]12[C@@](CC[C@]3([H])[C@]2([H])C[C@@H](O)[C@@]4(C)[C@]3(O)CC[C@@H]4C(CO5)=CC5=O)([H])C[C@@H](O[C@]6([H])O[C@H](C)[C@@H](O[C@@]7([H])C[C@H](O)[C@H](O[C@]8([H])O[C@H](C)[C@@H](O)[C@@H](O)C8)[C@@H](C)O7)[C@@H](O)C6)CC1
Molecular Weight 780,9
Formulation A crystalline solid
Purity ≥98%
Custom Code 2932.99
UNSPSC code 12352100

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