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Temozolomide-d3

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    Temozolomide<wbr/>-d<sub>3</sub>
  • Temozolomide<wbr/>-d<sub>3</sub>
Cat No: 22372
Biochemicals - Analytical Standards
Cayman
€143.00
Price is excluding VAT and does not include packaging neither shipping

An internal standard for the quantification of temozolomide by GC- or LC-MS,
Temozolomide-d3 (TMZ-d3) contains three deuterium atoms located on the methyl group. It is intended for use as an internal standard for the quantification of temozolomide (Ite...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 3,4-dihydro-3-(methyl-d3)-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide
  • Methazolastone-d3
  • TMZ-d3
Correlated keywords:
  • deuterated
  • GC-MS
  • GC/MS
  • LC/MS
  • GCMS
  • LCMS
  • CCRG-81045
  • CCRG81045
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Product Overview:
An internal standard for the quantification of temozolomide by GC- or LC-MS,
Temozolomide-d3 (TMZ-d3) contains three deuterium atoms located on the methyl group. It is intended for use as an internal standard for the quantification of temozolomide (Item No. 14163) by GC- or LC-MS. TMZ is an imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells. TMZ is rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier. Formulations containing TMZ are effective in a variety of types of cancer, including aggressive brain cancers.
Size 500 µg
Shipping dry ice
Stability Store at 2-8 degrees; shelf life 730 days maximum after production
CAS Number 208107-14-6
Molecular Formula C6H3D3N6O2
SMILES O=C(N(C([2H])([2H])[2H])N=N1)N2C1=C(C(N)=O)N=C2
Molecular Weight 197.2
Formulation A solid
Purity ≥99% deuterated forms (d1-d3)
Custom Code 2933290000
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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