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Colistin (sulfate)

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    Colistin (sulfate)
  • Colistin (sulfate)
Cat No: 17584

Colistin is a complex antibiotic containing greater than 30 components, with the cyclic polypeptide antibiotics polymyxins E1 (colistin A) and E2 (colistin B) as the major components.{40859,43058} It was originally isolated from B. polymyxa.{40859} Co...


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Territorial Availability: Available through Bertin Technologies only in France
  • Colistin, sulfate salt (2:5)
Correlated keywords:
  • 1264-72-8 7722-44-3 207990-63-4 1066-17-7 8055-19-4 11039-78-4 12737-32-5 51810-43-6 55606-05-8 126777-31-9 Colimycin Colomycin syrup Polymyxin E antibacterial Belcomycin nipoxyme 1264-72-8 Escherichia Pseudomonas Salmonella Listeria Lactococcus Paenibacillus Pediococcus Staphylococcus Klebsiella
Product Overview:
Colistin is a complex antibiotic containing greater than 30 components, with the cyclic polypeptide antibiotics polymyxins E1 (colistin A) and E2 (colistin B) as the major components.{40859,43058} It was originally isolated from B. polymyxa.{40859} Colistin inhibits the growth of the Gram-negative bacteria E. coli, P. aeruginosa, P. fluorescens, and S. enterica (MICs = 0.04-2.08 μg/ml) and Gram-positive L. ivanovii and L. monocytogenes (MICs = 2.5-10 μg/ml) but is not active against Gram-positive L. lactis, P. polymyxa, P. acidilactici, or S. aureus at concentrations up to 5 μg/ml.{40860} It also inhibits the growth of clinical isolates of both susceptible and multidrug-resistant P. aeruginosa (MICs = 1-2 mg/l).{40861} Colistin binds selectively to LPS from susceptible strains of K. pneumoniae compared to resistant strains (Kis = 0.56 and 2.83 μM, respectively), which may contribute to its mechanism of action against Gram-negative bacteria.{40863} In vivo, colistin slows the growth of P. aeruginosa and A. baumannii in a neutropenic mouse model of thigh infection.{40862}
Size 1 g
Shipping room temp.
Molecular Formula [C52H98N16O13]2 • 5H2SO4
SMILES O=S(O)(O)=O.O=S(O)(O)=O.O=S(O)(O)=O.O=S(O)(O)=O.O=S(O)(O)=O.O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CCNC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC1=O)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)CCN)=O)=O)=O)CCN)=O)[C@H](O)C)=O)CCN)CCCC[C@@H]
Molecular Weight 2801,3
Formulation A crystalline solid
Purity ≥95%
Custom Code 2922.19
UNSPSC code 12352100

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