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JNJ-26481585

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    JNJ-<wbr/>26481585
  • JNJ-<wbr/>26481585
Cat No: 14088
Biochemicals - Small Molecule Inhibitors
Cayman
€86.00
Price is excluding VAT and does not include packaging neither shipping

JNJ-26481585 is a hydroxamate-based HDAC inhibitor that shows activity toward all HDAC enzymes with highest potency in vitro toward HDAC1 (IC50 = 0.11 nM).{32219} For other HDACs, IC50 values range from 0.33, 0.37, and 0.46 nM for HDACs 2, 11, and 10,...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • N-hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-5-pyrimidinecarboxamide
Correlated keywords:
  • JNJ26481585 hydroxamate histone deacetylase HDAC HDAC1 apoptosis Ras HCT116 cycle-arrest
Product Overview:
JNJ-26481585 is a hydroxamate-based HDAC inhibitor that shows activity toward all HDAC enzymes with highest potency in vitro toward HDAC1 (IC50 = 0.11 nM).{32219} For other HDACs, IC50 values range from 0.33, 0.37, and 0.46 nM for HDACs 2, 11, and 10, respectively, to 32, 77, and 119 nM for HDACs 9, 6, and 7, respectively.{32219} JNJ-26481585 induces apoptosis and cell cycle arrest in multiple myeloma cells and complete tumor growth inhibition in Ras mutant HCT116 colon carcinoma or multiple myeloma xenografts.{32219,32220}
Size 1 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 875320-29-9
Molecular Formula C21H26N6O2
SMILES CN(C1=C2C=CC=C1)C=C2CNCC3CCN(C4=NC=C(C(NO)=O)C=N4)CC3
Molecular Weight 394,5
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.49
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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