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(±)-SLV 319

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    (±)-<wbr/>SLV 319
  • (±)-<wbr/>SLV 319
Cat No: 10009226
Price is excluding VAT and does not include packaging neither shipping

A mixture of the potent and selective CB1 receptor antagonist SLV 319 (Ki = 7.8 nM) and its distomer, SLV 319 (+)-enantiomer
Central cannabinoid (CB1) receptor antagonists may have potential in the treatment of a number of diseases such as neuroinflam...


This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe. This product is intended for forensic and research applications.
Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substances laboratories and qualified academic research institutions. Please consult our General Terms and conditions of Sales for further details.
  • 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-1H-pyrazole-1-carboximidamide
Correlated keywords:
  • CB1
  • CB2
  • Receptors
  • Cannabinoids
  • Antagonists
  • Inflammations
  • inflammatory
  • neurochemistry
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Product Overview:
A mixture of the potent and selective CB1 receptor antagonist SLV 319 (Ki = 7.8 nM) and its distomer, SLV 319 (+)-enantiomer
Central cannabinoid (CB1) receptor antagonists may have potential in the treatment of a number of diseases such as neuroinflammatory disorders, cognitive disorders, septic shock, obesity, psychosis, addiction, and gastrointestinal disorders. (±)-SLV 319 is the mixture of the CB1 receptor antagonist SLV 319 and its distomer, SLV 319 (+)-enantiomer. SLV 319 is a potent and selective CB1 receptor antagonist with Ki values of 7.8 and 7,943 nM for CB1 and peripheral cannabinoid (CB2), respectively. SLV 319 is less lipophilic (log P = 5.1) and therefore more water soluble than other known CB1 receptor ligands.
Size 1 mg
Shipping wet ice
Stability Store at -20 degrees; shelf life 730 days maximum after production
CAS Number 362519-49-1
Molecular Formula C23H20Cl2N4O2S
SMILES ClC(C=C1)=CC=C1C2=NN(/C(NC)=N/S(C3=CC=C(Cl)C=C3)(=O)=O)CC2C4=CC=CC=C4
Molecular Weight 487.4
Formulation A crystalline solid
Purity ≥98%
Custom Code 2930902000
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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