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Dutasteride

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    Dutasteride
  • Dutasteride
Cat No: 15956
Cayman
€73.00
Price is excluding VAT and does not include packaging neither shipping

An inhibitor of steroid 5α-reductase types I and II (Kis = 6 and 7 nM, respectively); a time-dependent inhibitor with apparent Ki values of 17 and 4.3 nM at 10- and 30-minute reaction times, respectively; decreases prostate weight in a rat model of ben...

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • N-[2,5-bis(trifluoromethyl)phenyl]-2,4aR,4bS,5,6,6aS,7S,8,9,9aS,9bS,10,11,11aR-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide
Correlated keywords:
  • 1169835-56-6
  • veltride
  • androgen
  • Avodart
Product Overview:
An inhibitor of steroid 5α-reductase types I and II (Kis = 6 and 7 nM, respectively); a time-dependent inhibitor with apparent Ki values of 17 and 4.3 nM at 10- and 30-minute reaction times, respectively; decreases prostate weight in a rat model of benign prostatic hypertrophy induced by testosterone at 0.045 and 0.756 mg/kg administered as a solution or in subcutaneous microspheres, respectively, daily for 28 days; also decreases prostate weight in a transgenic model of prostate cancer
Dutasteride is a dual inhibitor of 5α-reductase types I and II (Kis = 6 and 7 nM, respectively). Its inhibition is time-dependent inhibitor with apparent Ki values of 17 and 4.3 nM at 10- and 30-minute reaction times, respectively. Dutasteride decreases prostate weight in a rat model of benign prostatic hypertrophy induced by testosterone after castration when administered daily for 28 days at doses of 0.045 mg/kg as a solution or 0.756 mg/kg in subcutaneous microspheres. It also decreases prostate weight in large probasin-large T antigen mice, a transgenic model of prostate cancer. Formulations containing dutasteride have been used in the treatment of benign prostatic hyperplasia.
Size 5 mg
Shipping wet ice
Stability Store at -20 degrees; shelf life 730 days maximum after production
CAS Number 164656-23-9
Molecular Formula C27H30F6N2O2
SMILES O=C1C=C[C@@]2(C)[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(NC5=CC(C(F)(F)F)=CC=C5C(F)(F)F)=O)([H])N1
Molecular Weight 528.5
Formulation A crystalline solid
Purity ≥98%
Custom Code 2922199619
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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