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Hydroxy Bupropion

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    Hydroxy Bupropion
  • Hydroxy Bupropion
Cat No: 9000522
Biochemicals - Analytical Standards
Cayman
€36.00
Price is excluding VAT and does not include packaging neither shipping

Buproprion (Item No. 10488) is an inhibitor of the reuptake of dopamine and norepinephrine and is also an antagonist of neuronal acetylcholine nicotinic receptors. Because of its effects on nicotinic receptors, it is used to promote smoking cessation. ...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol
Correlated keywords:
  • inhibitors receptors antagonists neurosciences buproprions mix mixtures mixes enantiomers metabolisms cytochromes P450 CYP450 CYP-450 CYPs 450 cytochrome-P450 2B6 norepinephrines re-uptake reuptake re uptake inhibitions inhibits dopamines nicotinic smokes smoking smokers cessation metabolites hydroxybupropion hydroxy-bupropion neurons dopamines neuronal AchEs acetylcholines promotes racemic racemates isomers analytical references standards
Product Overview:
Buproprion (Item No. 10488) is an inhibitor of the reuptake of dopamine and norepinephrine and is also an antagonist of neuronal acetylcholine nicotinic receptors. Because of its effects on nicotinic receptors, it is used to promote smoking cessation. Hydroxy bupropion is a mixture of enantiomers produced by the metabolism of buproprion by cytochrome P450 2B6.{22910,22909} Compared with buproprion, this racemic mixture produces equal inhibition of norepinephrine reuptake (IC50 = 1.7 µM) and much weaker inhibition of dopamine reuptake (IC50 >10 µM).{22912} Moreover, hydroxyl bupropion isomers are potent antagonists of nicotinic receptors, suggesting that they may substitute for bupropion in smoking cessation.{22912,22911,22909}
Size 1 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 357399-43-0
Molecular Formula C13H18ClNO2
SMILES CC1NC(C)(C)COC1(C2=CC=CC(Cl)=C2)O
Molecular Weight 255,7
Formulation A crystalline solid
Purity ≥98%
Custom Code 2903.99
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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Cross selling for this product : Hydroxy Bupropion There are 7 products.

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