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Tomatidine (hydrochloride)

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    Tomatidine (hydrochloride)
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    Tomatidine (hydro<wbr>chloride)
  • Tomatidine (hydrochloride)
  • Tomatidine (hydro<wbr>chloride)
Cat No: 16938
Cayman
€33.00
Price is excluding VAT and does not include packaging neither shipping

A steroidal alkaloid with diverse biological activities; suppresses NF-κB signaling as well as iNOS and COX-2 expression in LPS-stimulated macrophages; inhibits acid sphingomyelinase activity at 10 mM; preferentially blocks replication of S. aureus var...

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • (3β,5α,22β,25S)-spirosolan-3-ol, monohydrochloride
Correlated keywords:
  • 77-59-8
  • biochemical
  • natural
  • product
  • inhibitor
  • inflammation
  • antibacterial
  • infectious
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Product Overview:
A steroidal alkaloid with diverse biological activities; suppresses NF-κB signaling as well as iNOS and COX-2 expression in LPS-stimulated macrophages; inhibits acid sphingomyelinase activity at 10 mM; preferentially blocks replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 µg/ml, respectively); prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice; has been used as a negative control for cyclopamine in studies involving signaling mediated by the hedgehog pathway
Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes. It suppresses NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of inducible nitric oxide synthase (iNOS) and COX-2. Tomatidine inhibits acid sphingomyelinase activity by 84.2% when used at a concentration of 10 mM. It also has antibacterial properties, preferentially blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis over normal strains (MICs = 0.12 and >16 µg/ml, respectively). It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice. Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.
Size 10 mg
Shipping wet ice
Stability Store at -20 degrees; shelf life 730 days maximum after production
CAS Number 6192-62-7
Molecular Formula C27H45NO2 • HCl
SMILES C[C@@H](CC1)CN[C@@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC[C@@]6([H])C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C.Cl
Molecular Weight 452.1
Formulation A crystalline solid
Purity ≥90%
Custom Code 2922199619
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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