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Pertussis Toxin (islet-activating protein)
Cat No: 19546
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Pertussis toxin (islet-activating protein) is a toxin, first isolated from B. pertussis, that is used to study G protein-coupled receptor signaling in cells and experimental autoimmune encephalomyelitis (EAE) in animals. Pertussis toxin catalyzes the ...
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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
- 82248-93-9 GPCR EAE encephalomyelitis ADP-ribose NAD Gi/o ?-adrenergic a-adrenergic AC Gi Bordetella Gio
Product Overview:
Pertussis toxin (islet-activating protein) is a toxin, first isolated from B. pertussis, that is used to study G protein-coupled receptor signaling in cells and experimental autoimmune encephalomyelitis (EAE) in animals. Pertussis toxin catalyzes the transfer of the ADP-ribose moiety of NAD to the α subunits of heterotrimeric Gi/o proteins, resulting in the receptors being uncoupled from Gi/o proteins.{31502,31505} Pertussis toxin is also used as an adjuvant, given with specific antigens, to immunize animals and induce EAE, an animal model of multiple sclerosis.{31501,31504} Pertussis toxin was first described as an islet-activating protein because it caused a sustained potentiation of the secretory response of pancreatic islet cells to various stimuli that stimulate Gi-linked α-adrenergic receptors.{31500,31503}
Pertussis toxin (islet-activating protein) is a toxin, first isolated from B. pertussis, that is used to study G protein-coupled receptor signaling in cells and experimental autoimmune encephalomyelitis (EAE) in animals. Pertussis toxin catalyzes the transfer of the ADP-ribose moiety of NAD to the α subunits of heterotrimeric Gi/o proteins, resulting in the receptors being uncoupled from Gi/o proteins.{31502,31505} Pertussis toxin is also used as an adjuvant, given with specific antigens, to immunize animals and induce EAE, an animal model of multiple sclerosis.{31501,31504} Pertussis toxin was first described as an islet-activating protein because it caused a sustained potentiation of the secretory response of pancreatic islet cells to various stimuli that stimulate Gi-linked α-adrenergic receptors.{31500,31503}
| Size | 50 µg |
| Shipping | wet ice |
| CAS Number | 70323-44-3 |
| Formulation | Each vial, when reconstituted to 500 ?l with water, contains 50 ?g of pertussis toxin in 0.03 M sodium phosphate, 0.05 M sodium chloride, pH 7.0 |
| Purity | ≥95% (estimated by SDS-PAGE) |
| Custom Code | 3504.00 |
| UNSPSC code | 12352100 |
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