2-furoyl-LIGRLO amide (trifluoroacetate salt)

Biochemicals - Receptor Pharmacology

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Cat No: 14594

Biochemicals - Receptor Pharmacology

2-furoyl-LIGRLO amide is a potent and selective agonist of the proteinase-activated receptor, PAR2 (pD2 = 7.0).{23092} It does not activate PAR1 or PAR4. Through its effects on PAR2, 2-furoyl-LIGRLO amide produces a concentration-dependent relaxation ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-(2-furanylcarbonyl)-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucyl-L-ornithinamide, trifluoroacetate

Correlated keywords:

2468029-34-5 729589-58-6 receptors agonists vascular diseases inflammation potent PAR2 PAR-2 PARs 2 two amides LIGRLO furoyl selectives proteinase-activated proteinase activated active arteries a1 adrenergic a-1 a 1 alpha1 alpha-1 alpha .alpha.1 .alpha.-1 .alpha. ?1 ?-1 ? relaxation relax TFA

Product Overview:
2-furoyl-LIGRLO amide is a potent and selective agonist of the proteinase-activated receptor, PAR2 (pD2 = 7.0).{23092} It does not activate PAR1 or PAR4. Through its effects on PAR2, 2-furoyl-LIGRLO amide produces a concentration-dependent relaxation of arteries previously contracted with α1 adrenergic receptor agonists.{23092}

Size	1 mg
Shipping	dry ice
Molecular Formula	C₃₆H₆₃N₁₁O₈ • XCF₃COOH
SMILES	O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCCN)C(N)=O)=O)=O)CNC([C@@H](NC([C@@H](NC(C1=CC=CO1)=O)CC(C)C)=O)[C@@H](C)CC)=O.FC(F)(C(O)=O)F
Molecular Weight	778
Formulation	A solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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