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Brimonidine (tartrate)

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    Brimonidine (tartrate)
  • Brimonidine (tartrate)
Cat No: 15426
Biochemicals - More Biochemicals
Cayman
€59.00
Price is excluding VAT and does not include packaging neither shipping

An ?2-AR agonist (Kis = 2.7, 52, and 44 nM for ?2A, ?2B, and ?2C-ARs, respectively, in CHO cells); selective for ?2-ARs over ?1-ARs (Ki = 1,800 nM in human brain); lowers intraocular pressure in DBA/2J mice to control levels at 0.1% applied topically t...

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, 2R,3R-dihydroxybutanedioate
  • AGN 190342LF
  • Alphagan P
Correlated keywords:
  • 59803-98-4
  • 79570-?19-?7
  • 109826-?56-?4
  • glaucoma
  • alphagan
  • alphagan-P
  • ocular
  • hypertension
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Product Overview:
An ?2-AR agonist (Kis = 2.7, 52, and 44 nM for ?2A, ?2B, and ?2C-ARs, respectively, in CHO cells); selective for ?2-ARs over ?1-ARs (Ki = 1,800 nM in human brain); lowers intraocular pressure in DBA/2J mice to control levels at 0.1% applied topically to the eye; protects rat retinal ganglion cells against glutamate excitotoxicity in a rat model of retinal ischemia at 1 mg/kg per day
Brimonidine is an agonist of ?2-adrenergic receptors (?2-ARs; Kis = 2.7, 52, and 44 nM for ?2A, ?2B, and ?2C-ARs, respectively, in CHO cells). It is selective for ?2-ARs over ?1-ARs (Ki = 1,800 nM in human brain). Brimonidine lowers intraocular pressure in DBA/2J mice, a model of glaucoma, to control levels when applied topically to the eye as a 0.1% solution. It also inhibits glutamate release, prevents upregulation of NMDA receptors containing NR1 and NR2A subunits, and protects rat retinal ganglion cells against glutamate excitotoxicity in a rat model of retinal ischemia when administered at a dose of 1 mg/kg per day. Formulations containing brimonidine have been used in the treatment of open-angle glaucoma and ocular hypertension.
Size 10 mg
Shipping wet ice
Stability Store at -20 degrees; shelf life 730 days maximum after production
CAS Number 70359-46-5
Molecular Formula C11H10BrN5 • C4H6O6
SMILES BrC1=C(NC2=NCCN2)C=CC3=C1N=CC=N3.O[C@H]([C@@H](O)C(O)=O)C(O)=O
Molecular Weight 442.2
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933497050
UNSPSC code 12352100
UN Number UN2811

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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