Leukotriene E4 ELISA Kit

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Leukotriene E₄ ELISA Kit

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Cat No: 501060

Assay Kits - Elisa

Leukotriene E4 (LTE4) is a product of the 5-lipoxygenase (5-LO) pathway in activated mast cells, eosinophils, and monocytes. LTA4, the primary 5-LO metabolite, is rapidly converted to LTC4 and sequentially to LTD4 and LTE4. While plasma levels of LTC4...

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Territorial Availability: Available through Bertin Technologies only in France

Special Advice: replacement of #520411

Correlated keywords:

LTE4 urine allergy asthma assay kit eicosanoid immunology inflammation leukotriene lipid mediator E4 LT quantification

Product Overview:
Leukotriene E4 (LTE4) is a product of the 5-lipoxygenase (5-LO) pathway in activated mast cells, eosinophils, and monocytes. LTA4, the primary 5-LO metabolite, is rapidly converted to LTC4 and sequentially to LTD4 and LTE4. While plasma levels of LTC4 are virtually undetectable, exogenously administered LTC4 is recovered in the urine as LTE4 (5-13%) and two prominent oxidized metabolites resulting from several cycles of β-oxidation. Cayman’s LTE4 ELISA Kit is a competitive assay developed for the measurement of LTE4 from urine without a purification step. The assay has a range of 7.8-1,000 pg/ml and a sensitivity (80% B/B0) of approximately 25 pg/ml. This “dilute and go” format has been used successfully to demonstrate significant and reproducible changes in LTE4 levels in the urine of asthmatic patients after antigen challenge. If your samples require additional purification prior to analysis, Cayman’s Cysteinyl Leukotriene Affinity Sorbent (Item No. 400396) can be used for this purpose.

Size	96 strip wells
Shipping	dry ice
Custom Code	3822.19
UNSPSC code	41116104

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.