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CD36 Monoclonal Antibody (Clone JC63.1) (Low Endotoxin)

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Cat No: 10009893
Cayman
€342.00
Price is excluding VAT and does not include packaging neither shipping

Antigen: recombinant adenovirus expressing full-length mouse CD36 • Host: CD36 null mouse, clone JC63.1 • Cross Reactivity: (+) human, mouse, and rat CD36 • Application(s): FC, functional blocking, and ICC • Functioning as a receptor for oxidized LDL...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Correlated keywords:
  • antibodies antisera antiserum flow cytometry PPAR.gamma. CD-36 glycoprotein fatty acids PPARgamma blocking apoptosis oxidative injury atherosclerosis FC leukemia lymphocytic
Product Overview:
Antigen: recombinant adenovirus expressing full-length mouse CD36 • Host: CD36 null mouse, clone JC63.1 • Cross Reactivity: (+) human, mouse, and rat CD36 • Application(s): FC, functional blocking, and ICC • Functioning as a receptor for oxidized LDL, CD36 is a type-B scavenger receptor that is necessary for the formation of foam cells and thereby atherosclerotic lesions.
CD36 is a type-B scavenger receptor that is necessary for the formation of foam cells and thereby atherosclerotic lesions. This membrane glycoprotein can internalize fatty acids which activate PPAR? and stimulate further expression of CD36. This positive feedback loop combined with the murine CD36 knock-out studies reinforces the importance of CD36 in lipid metabolism. Additionally CD36 is needed for the phagocytosis of P. falciparum infected erythrocytes, retinal pigment epithelial cell photoreceptor fragments and post-apoptotic monocytes and neutrophils. CD36 expression has been monitored during hematopoietic cell differentiation and may be an indicator of tumor spreading in lymphocytic leukemia. Positive controls include adipose and heart tissue, platelets, and macrophages.
Size 100 µg
Shipping dry ice
Host CD36 null mouse
Antigen Recombinant adenovirus expressing full-length mouse CD36
Clone JC63.1
Isotype IgA
Application(s)

FC, functional blocking, ICC

Formulation 100 μg or 500 μg of purified IgA
Custom Code 3822.00
UNSPSC code 12352203

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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