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Gly-Phe-?-naphthylamide

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    Gly-<wbr/>Phe-<wbr/>?-<wbr/>naphthylamide
  • Gly-<wbr/>Phe-<wbr/>?-<wbr/>naphthylamide
Cat No: 14634
Cayman

Cathepsin C is a lysosomal cysteine protease with broad exopeptidase activity that progressively removes dipeptides from various protein and polypeptides substrates.{23422} Aside from its role in post-translational processing, cathepsins may also parti...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • glycyl-N-2-naphthalenyl-L-phenylalaninamide
Correlated keywords:
  • dipeptidyl transferase cathepsins C lysosomes proteases apoptosis caspases substrates posttranslational cathepsin-C membranes intralysosomal cysteine exopeptidase dipeptides polypeptides cytosolic proapoptotic hydrolysis caspase-8 caspase 8
Product Overview:
Cathepsin C is a lysosomal cysteine protease with broad exopeptidase activity that progressively removes dipeptides from various protein and polypeptides substrates.{23422} Aside from its role in post-translational processing, cathepsins may also participate in apoptotic signaling pathways by targeting cytosolic caspases and proapoptotic proteins.{23423} Gly-Phe-β-naphthylamide is a substrate of cathepsin C that accumulates within the lysosome. Hydrolysis by cathepsin C degrades Gly-Phe-β-naphthylamide into fragments that do not easily diffuse through the lysosomal membrane, leading to a loss of lysosome membrane integrity.{23424} This compound has been used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C.{23422,23424} At 50 μM, Gly-Phe-β-naphthylamide can inhibit the cathepsin-dependent activation of caspase-8.{23423}
Size 50 mg
Shipping dry ice
CAS Number 21438-66-4
Molecular Formula C21H21N3O2
SMILES NCC(N[C@@H](CC1=CC=CC=C1)C(NC2=CC(C=CC=C3)=C3C=C2)=O)=O
Molecular Weight 347,4
Formulation A crystalline solid
Purity ≥95%
Custom Code 2922.19
UNSPSC code 12352100

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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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