Dihydrolipoic Acid

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Dihydrolipoic Acid

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Cat No: 16372

Biochemicals - Ox Stress Reagents

Dihydrolipoic acid (DHLA) is a dithiol-containing carboxylic acid that is the reduced form of α-lipoic acid (Item No. 10005728). It acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including hydroxyl ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

6,?8-?dimercapto-octanoic acid

Correlated keywords:

7516-?48-?5 119365-69-4 98441-85-1 36915-02-3 ?-lipoic acids antioxidants ROSs reactive oxygens species apoptosis cells deaths dithiol-containing dithiols containing carboxylic embryonic stems cancers proliferations (±)?-?Dihydro-??-?lipoic (±)?-?Dihydrolipoic 6,?8-?Dihydrothioctic 6,?8-?Dimercaptooctanoic 6,?8-?Dithiooctanoic DL-?Dihydro-??-?lipoic DL-?Dihydro-?a-?lipoic DL-?Dihydro-?alpha-?lipoic DL-?Dihydro-.alpha.-?lipoic Dihydrothioctic Reduced lipoic thioctic dl-?Dihydrolipoic ?-?Lipoic ?-?Lipoic

Product Overview:
Dihydrolipoic acid (DHLA) is a dithiol-containing carboxylic acid that is the reduced form of α-lipoic acid (Item No. 10005728). It acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including hydroxyl radicals, peroxynitirite, hydrogen peroxide, and hypochlorite, at concentrations ranging from 0.01-0.5 mM.{26768} At concentrations of 50-100 µM, DHLA triggers apoptosis of mouse embryonic stem cells and human cancer cells, suppressing proliferation.{26767}

Size	25 mg
Shipping	dry ice
CAS Number	462-20-4
Molecular Formula	C₈H₁₆O₂S₂
SMILES	OC(CCCCC(S)CCS)=O
Molecular Weight	208,3
Formulation	A neat oil
Purity	≥95%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.