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Phenylmethylsulfonyl fluoride

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    Phenylmethyl<wbr/>sulfonyl fluoride
  • Phenylmethyl<wbr/>sulfonyl fluoride
Cat No: 14333
Biochemicals - Labeling & Detection
Cayman
€40.00
Price is excluding VAT and does not include packaging neither shipping

Phenylmethylsulfonyl fluoride (PMSF) is a nonspecific, irreversible inhibitor of serine proteases and other enzymes, including acetylcholinesterase, palmityl coenzyme A deacylase, arylsulfatase A, chymotrypsin, and trypsin.{22801,22800} It is used in ...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Specific regulation - Please contact Bertin Technologies Customer Service
Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substances laboratories and qualified academic research institutions. Please consult our Sales Conditions.
Special Advice: Dangerous Good in said quantity, please order same item in smaller packaging
Synonyms:
  • benzenemethanesulfonyl fluoride
Correlated keywords:
  • inhibitors enzymes activity protease inhibits inhibitions α-toluenesulfonyl fluorides a-toluenesulfonyl alpha-toluenesulfonyl .alpha.-toluenesulfonyl serines proteases acetylcholinesterase palmityl coenzymes A deacylases arylsulfatases A chymotrypsin trypsin proteins solublization soluble cells lysis anandamides coenzymes antinociception conenzyme-A nonspecific irreversible deactive serines blocking blocks metabolisms cannabinoids CBs effects hypothermia immobility benzylsulfonyl NSCs 88499 NSC-88499 NSC88499
Product Overview:
Phenylmethylsulfonyl fluoride (PMSF) is a nonspecific, irreversible inhibitor of serine proteases and other enzymes, including acetylcholinesterase, palmityl coenzyme A deacylase, arylsulfatase A, chymotrypsin, and trypsin.{22801,22800} It is used in protein solublization studies in order to deactivate proteases from digesting proteins of interest after cell lysis. Because PMSF specifically sulfonylates the hydroxal groups of active site serine residues of enzymes, it can be used as a chemical label to identify essential active site serines in an enzyme. PMSF is known to alter the actions of anandamide by blocking its metabolism and can produce cannabinoid effects in mice, including antinociception, hypothermia, and immobility with ED50 values of 86, 224, and 206 mg/kg, respectively.{12727}
Size 5 g
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 329-98-6
Molecular Formula C7H7FO2S
SMILES FS(CC1=CC=CC=C1)(=O)=O
Molecular Weight 174,2
Formulation A crystalline solid
Purity ≥98%
Custom Code 2903.99
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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