Triptolide

Confirm delete?

Triptolide

Zoom

Cat No: 11973

Biochemicals - Natural Products

Triptolide is a diterpenoid triepoxide that has been found in T. wilfordii and has diverse biological activities.{22058,57803,57804,57805} It inhibits dCTP pyrophosphatase 1 (Ki = 168 µM), an enzyme that prevents halogenated nucleotides from entering ...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3bS,4,4aS,6R,6aR,7aS,7bS,8bS,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-trisoxireno[4b,5aS:6,7:8aS,9]phenanthro[1,2-c]furan-1(3H)-one

Correlated keywords:

NSC163062 NSC-163062 PG490 PG-490 triptolid natural products antiproliferative immunosuppressive anti-inflammatory polycystic kidney disease dCTP pyrophosphatase 1 DCTPP1 DNA synthesis COX-2 COX cyclooxygenase 2 PGE2 prostaglandins E2 PGs tripterygium wilfordii hook F thunder god vine Chinese medicinal herbs antifertility antipolycystic binds inhibits inhibitors inhibitions LPS Tripterygium NCIH520 NCIH1650

Product Overview:
Triptolide is a diterpenoid triepoxide that has been found in T. wilfordii and has diverse biological activities.{22058,57803,57804,57805} It inhibits dCTP pyrophosphatase 1 (Ki = 168 µM), an enzyme that prevents halogenated nucleotides from entering DNA synthesis.{22058} It reduces viability of A549, H1299, NCI H520, NCI H1650, and H1975 human non-small cell lung cancer (NSCLC) cells when used at a concentration of 50 nM.{57803} Intranasal administration of liposomes containing triptolide (0.4 mg/kg) reduces tumor growth in a rat orthotopic model of lung cancer. Triptolide (0.2 mg/kg) reduces intestinal inflammation and prevents colon shortening in a mouse model of colitis induced by dextran sulfate (Item No. 23250).{57804} It also inhibits skin allograft rejection and increases graft survival time in mice when administered at a dose of 0.1 mg/kg per day post-transplantation.{57805}

Size	1 mg
Shipping	dry ice
CAS Number	38748-32-2
Molecular Formula	C₂₀H₂₄O₆
SMILES	C[C@@]12[C@]3([C@H]([C@H]4[C@]5(C(C)C)O4)O3)[C@@]([C@@H]5O)(O6)[C@@H]6C[C@@]1([H])C(COC7=O)=C7CC2
Molecular Weight	360,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.