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Tetrodotoxin (citrate)

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    Tetrodotoxin (citrate)
  • Tetrodotoxin (citrate)
Cat No: 14964
Biochemicals - Ion Channel Modulation
Price is excluding VAT and does not include packaging neither shipping

TTX is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (Nav) channels, blocking nerve and muscle action potentials. It inhibits the Nav current in frog muscle and squid axon with IC...

: 1 mg

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Territorial Availability: Specific regulation - Please contact Bertin Technologies Customer Service
Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substances laboratories and qualified academic research institutions. Please consult our Sales Conditions.
Special Advice: LETTER OF ASSURANCE NEEDED - special handling and administrative fees : 150€
  • (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-2-amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-5,9:7,10a-dimethanol-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol, citrate
Correlated keywords:
  • 18660-81-6 TTX puffer fish neurotoxins sodium channels blockers inward currents voltage-activated Na+ NaV actions potentials inhibitors neuroscience neurons neuropathic pains soluble marine voltages activated nerves muscles Hodgkin Huxley’s ions pumps blockers natural products Na V volts BJT 1 one PFT-1 Toxins Spheroidine Babylonia japonica
Product Overview:
TTX is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (Nav) channels, blocking nerve and muscle action potentials. It inhibits the Nav current in frog muscle and squid axon with IC50 values of 4.1 and 5.2 nM, respectively, and binds to rat brain membranes with a Kd value of 1.8 nM.{23790} TTX was used in Hodgkin and Huxley’s classic experiments to elucidate the physical biology of nerve action potentials and remains an indispensible neuroscience tool to pharmacologically dissect the contribution of the Nav current in excitable neurons and to rationally design compounds for the treatment of neuropathic pain.{23790} This citrate-stabilized form of TTX is designed for improved solubility over pure TTX (Item No. 14963), which is insoluble in water and most organic solvents. This preparation of TTX citrate consists of TTX that has been dissolved in a citrate solution and then lyophilized.
Size 1 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 18660-81-6
Molecular Formula C11H17N3O8
SMILES NC1=N[C@H](O)[C@@]2([H])[C@]3([H])[C@](CO)(O)[C@]([H])([C@@]4([H])O)O[C@@](O)(O3)[C@@H](O)[C@@]24N1
Molecular Weight 319,3
Formulation A solid
Purity ≥98%
Custom Code 2906.13
UNSPSC code 12352100

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