Scavenger Receptor B2/CD36 Monoc

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Scavenger Receptor B2/CD36 Monoclonal Antibody (Clone JC63.1)

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Cat No: 188150

CD36, also known as scavenger receptor B2 (SR-B2) or fatty acid translocase (FAT), is a transmembrane glycoprotein that has roles in fatty acid uptake and lipid metabolism and signaling.{62494} It is composed of N- and C-terminal cytoplasmic tails, tw...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

CD-36 SRB2 TSP1 posttranslational sCD-36 STAT-2 HIF1? Plasmodium Hexarelin Receptor oxLDL Receptor GP-IIIb GP-IV PASIV

Product Overview:
CD36, also known as scavenger receptor B2 (SR-B2) or fatty acid translocase (FAT), is a transmembrane glycoprotein that has roles in fatty acid uptake and lipid metabolism and signaling.{62494} It is composed of N- and C-terminal cytoplasmic tails, two transmembrane domains, and an extracellular loop that binds to a variety of lipid ligands, including long-chain fatty acids, oxidized LDL, and oxidized phospholipids, and protein ligands, such as thrombospondin (TSP-1), and is subject to post-translational modifications.{62494,62495,62496} CD36 is expressed by a variety of cells, including hematopoietic cells such as platelets, monocytes, and macrophages, as well as adipocytes, enterocytes, cardiac and skeletal myocytes, and endothelial and epithelial cells.{62494,62497} It also exists as a soluble form, sCD36, which is produced via plasma proteases.{62495} CD36 expression is regulated by several transcription factors, including peroxisome proliferator-activated receptor (PPAR), STAT3, and hypoxia-inducible factor-1α (HIF-1α), in a tissue-dependent manner.{62496,62494} It is localized to the plasma membrane and within endosomes, the endoplasmic reticulum, and mitochondria, and is translocated between these compartments in response to various stimuli, including insulin-induced PI3K signaling and muscle contraction-induced AMPK signaling, to regulate fatty acid uptake.{62495,62496} It has additional roles in the phagocytosis of apoptotic cells and P. falciparum-infected red blood cells (RBCs), angiogenesis, thrombosis, inflammation, and atherosclerosis, as well as cancer metastasis.{62498,62496} Cayman's Scavenger Receptor B2/CD36 Monoclonal Antibody (Clone JC63.1) can be used for flow cytometry (FC) applications.

Size	100 µg
Shipping	dry ice
Host	CD36 null mouse
Antigen	Recombinant full-length mouse CD36 expressed in adenovirus
Clone	JC63.1
Isotype	IgA
Application(s)	FC
Formulation	100 µg of protein L-purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.