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S-Catechol O-Methyltransferase (human, recombinant)

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    S-Catechol O-<wbr/>Methyl<wbr>transferase (human, recombinant)
  • S-Catechol O-<wbr/>Methyl<wbr>transferase (human, recombinant)
Cat No: 15563
Proteins - Enzymes

S-Catechol-O-methyltransferase (S-COMT) is the soluble cytosolic form of COMT.{26887} A rough endoplasmic reticulum membrane-bound form of COMT (MB-COMT) is also encoded by the COMT gene but produced via a separate promoter and contains an additional ...

: 100 µg

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • SCOMT MBCOMT Val 158 Met SARSCoV2 CoV2 coronavirus anti-viral covid-19 covid19 corona virus
Product Overview:
S-Catechol-O-methyltransferase (S-COMT) is the soluble cytosolic form of COMT.{26887} A rough endoplasmic reticulum membrane-bound form of COMT (MB-COMT) is also encoded by the COMT gene but produced via a separate promoter and contains an additional 50 amino acid residues, which compose the membrane anchor region.{26887,26884} COMT is comprised of one domain with eight α helices surrounding a central β sheet.{55023} It is the methyltransferase responsible for transferring a methyl group from S-adenosyl-L-methionine (SAM) to a catechol hydroxyl in the inactivation or degradation of catechol-containing molecules such as catecholamines.{26885} S-COMT is involved primarily in the inactivation of endogenous and xenobiotic catechols, such as catechol-containing hormones and carcinogenic flavonoids, and MB-COMT is involved primarily in the degradation of endogenous catecholamine neurotransmitters.{26885,26888} S-COMT is the predominant form of COMT and is found primarily in the liver and kidney but is also found in the stomach, small intestine, adrenal gland, spleen, and brain.{55021} A valine-to-methionine substitution (Val158Met) in COMT affects its thermostability and may reduce its activity by greater than 50% in the human brain.{26886} The Val158Met variant of COMT is associated with Parkinson’s disease in an ethnicity-dependent manner.{55022} COMT interacts with severe acute respiratory coronavirus 2 (SARS-CoV-2) non-structural protein 7 (Nsp7), which, together with Nsp8, forms the primase complex of the replicase-transcriptase complex of SARS-CoV-2.{55024} Cayman’s S-Catechol-O-Methyltransferase (human, recombinant) protein can be used for ELISA, Western blot (WB), and enzyme activity assay applications.
Size 100 µg
Shipping dry ice
Formulation 50 mM Hepes, pH 8.0, with 500 mM NaCl and 10% glycerol
Purity ≥70% estimated by SDS-PAGE
Custom Code 3504.00
UNSPSC code 12352204

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