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Catechol O-Methyltransferase (human recombinant)

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    Catechol O-<wbr/>Methyl<wbr>transferase (human recombinant)
  • Catechol O-<wbr/>Methyl<wbr>transferase (human recombinant)
Cat No: 15563
Proteins - Enzymes
Cayman
€521.00
Price is excluding VAT and does not include packaging neither shipping

Catechol-O-methyltransferase (COMT) plays an important role in normal brain function and has been implicated in human disorders, such as Parkinson's disease. Using S-adenosyl-L-methionine (SAM) as a methyl donor, COMT methylates catechol substrates, w...

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: 100 µg

This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Correlated keywords:
  • COMT SCOMT regulator cortex dopamine cognition protein P21964 P-21964
Product Overview:
Catechol-O-methyltransferase (COMT) plays an important role in normal brain function and has been implicated in human disorders, such as Parkinson's disease. Using S-adenosyl-L-methionine (SAM) as a methyl donor, COMT methylates catechol substrates, which include neurotransmitters, such as dopamine, norepinephrine, epinephrine, and catecholestrogens; ascorbic acid; and carcinogenic flavonoids.{26885} There are two classes of COMT, the soluble cytosolic form (S-COMT), and the rough endoplasmic reticulum membrane bound form (MB-COMT).{26887} Both forms are coded by a single gene using two separate promoters.{26887} Cayman’s COMT is the soluble S-COMT isoform and is composed of 221 amino acids, whereas MB-COMT has an additional 50 amino acid residues, including 21 hydrophobic amino acid residues that compose the membrane anchor region.{26884} While S-COMT is predominate in most tissues, MB-COMT is found in higher concentrations in the brain.{26888} A common variant in exon 4 of the COMT gene leads to a substitution of valine by methionine, Val158Met, which affects the stability of COMT and may diminish activity by 50% in the human brain. Since COMT is one of the primary regulators of prefrontal cortex dopamine levels, it plays an important role in cognition.{26886}
Size 100 µg
Shipping dry ice
Stability Store at -80 degrees; shelf life 180 days
Formulation 50 mM Hepes, pH 8.0, 500 mM NaCl, 10% glycerol
Purity ≥70% estimated by SDS-PAGE
Custom Code 3504.00
UNSPSC code 12352204

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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