TYK2 (human, recombinant)

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Cat No: 33745

Proteins - Enzymes

Tyrosine kinase 2 (TYK2) is a member of the JAK family of non-receptor tyrosine kinases that has a key role in cytokine signaling.{62097,62098} It is composed of an N-terminal FERM homology domain, which mediates protein-protein interactions, a Src-ho...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

TYK IL12R?1 IL10R2 gp-130 IL13R?1 JAK

Product Overview:
Tyrosine kinase 2 (TYK2) is a member of the JAK family of non-receptor tyrosine kinases that has a key role in cytokine signaling.{62097,62098} It is composed of an N-terminal FERM homology domain, which mediates protein-protein interactions, a Src-homology 2 (SH2) domain, a catalytically inactive pseudokinase domain, and a catalytically active C-terminal kinase domain.{62097} TYK2 is expressed by a variety of immune cells, including T and B cells, dendritic cells, mast cells, and macrophages, where it associates with numerous cytokine receptor chains, including IFNARI, IL-12Rβ1, IL-10R2, gp130, and IL-13Rα1, to mediate STAT-dependent cytokine signaling.{62098,62097,62099} TYK2 is activated by its phosphorylation, which is induced by ligand-bound cytokine receptors via JAK1 or JAK2-mediated transactivation, and is inhibited by suppressor of cytokine signaling (SOCS) proteins.{62099} TYK2 has roles in numerous immunological processes, including inflammatory and autoimmune diseases, pathogen defense, and allergy, as well as tumor surveillance and cancer.{62097,62099} TYK2 SNPs have been identified in patients with acute myeloid leukemia, and TYK2 polymorphisms have been associated with systemic lupus erythematosus (SLE) and multiple sclerosis in humans.{62097} Cayman's TYK2 (human, recombinant) protein can be used for enzyme activity assays.

Size	10 µg
Shipping	dry ice
Formulation	45 mM Tris, pH 8.0, with 125 mM NaCl, 2.4 mM KCl 0.045%, 100 mM imidazole, and 10% glycerol
Purity	≥90% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

Technical File

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.