Follistatin (human, recombinant)

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Cat No: 31839

Proteins - More Proteins

Follistatin is a glycoprotein with roles in the reproductive system, as well as during development and in cell growth and differentiation.{61343,61344} It is composed of an N-terminal region, three 10-cysteine follistatin domains (FSDs), and a C-termi...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

HEK-293 FS288 FS315 FS303 TGF?

Product Overview:
Follistatin is a glycoprotein with roles in the reproductive system, as well as during development and in cell growth and differentiation.{61343,61344} It is composed of an N-terminal region, three 10-cysteine follistatin domains (FSDs), and a C-terminal segment.{61345} Alternative splicing of FST, the gene encoding follistatin, generates two isoforms: FS-288 and FS-315, which differ in the length of the C-terminal region, and a third isoform, FS-303, is formed through proteolytic cleavage of FS-315.{61345,61343,61346} Follistatin is ubiquitously expressed and primarily secreted but is found in the cytosol of certain cells.{61344,61346} It binds to proteins in the TGF-β superfamily, including activin, inhibin, and myostatin, and prevents them from interacting with their respective receptors. This inhibition of TGF-β family proteins leads to a wide variety of effects on inflammation, immunity, muscle formation, and cancer, among others.{61343,61364,61365} Overexpression of FST in breast cancer cells in vitro reduces cell growth rate, and FST expression in breast cancer is associated with increased relapse-free survival.{61365} FST gene therapy increases muscle mass and reduces knee inflammation in a mouse model of high-fat diet-induced obesity and surgically induced osteoarthritis.{61366} Cayman’s Follistatin (human, recombinant) protein can be used for ELISA and binding assay applications. This protein is a disulfide-linked homodimer. The reduced monomer, composed of follistatin (amino acids 30-344) fused to human IgG1 Fc at its C-terminus, consists of 556 amino acids and has a calculated molecular weight of 61.7 kDa. As a result of glycosylation, the monomer migrates at approximately 70 kDa by SDS-PAGE under reducing conditions.

Size	50 µg
Shipping	dry ice
Formulation	Lyophilized from sterile PBS, pH 7.4
Purity	≥85% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

Technical File

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.