Satratoxin G

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Satratoxin G

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Cat No: 9003415

Biochemicals - Toxins

Satratoxin G is a macrocyclic trichothecene mycotoxin that has been found in S. chartarum.{53279,53280} It induces cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP) in HL-60 cells when used at a concentration of 40 nM and is cytotoxic to He...

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Territorial Availability: Available through Bertin Technologies only in France

                                            Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.
                    

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Synonyms:

6,8a,11a,12,21,22-hexahydro-23-hydroxy-19-(1-hydroxyethyl)-7,11a-dimethyl-spiro[10,12:19,22a-dimethano-4H,5H,22aH-oxireno[8,9][1,6,12]trioxacyclooctadecino[3,4-d][1]benzopyran-11(10H),2?-oxirane]-2,14(1aH,19H)-dione

Correlated keywords:

Stachybotrys HL60 Hep-G2 Hep2 Caco2 A-204 U-937 IL1? IL1? IL6 TNF? MIP2

Product Overview:
Satratoxin G is a macrocyclic trichothecene mycotoxin that has been found in S. chartarum.{53279,53280} It induces cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP) in HL-60 cells when used at a concentration of 40 nM and is cytotoxic to HepG2, Hep-2, Caco-2, A204, U937, and Jurkat cells (IC50s = 2.2-9.7 ng/ml).{53281,53282} Intranasal administration of satratoxin G (500 μg/kg) induces apoptosis of olfactory sensory neurons in olfactory epithelium and ethmoid turbinate expression of the genes encoding IL-1α, IL-1β, IL-6, TNF-α, and MIP-2 in mice.{53280} Satratoxin G induces lethality in 4 week-old male mice (LD50 = 1.23 mg/kg, i.p.).{53279}

Size	1 mg
Shipping	dry ice
CAS Number	53126-63-9
Molecular Formula	C₂₉H₃₆O₁₀
SMILES	O=C(/C=C\C=C\C1(C(O)C)C(O)C2(C3O2)CCO1)OC4CC(C56OC6)OC(C=C(C)CC7)C7(COC3=O)C45C
Molecular Weight	544,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2934.99
UNSPSC code	12352100

Technical File

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.