IgG3 (human) Rabbit Monoclonal A

Confirm delete?

IgG3 (human) Rabbit Monoclonal Antibody - Biotinylated

Zoom

Cat No: 32375

Immunoglobulin G (IgG) is a member of the immunoglobulin superfamily of glycoproteins that plays a central role in the adaptive immune response.{28520} It is produced by B cells and later secreted by plasma cells and is the most abundant circulating a...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

RM 119 IgG 1 2 2a 2b 2c 3 4 HIV1

Product Overview:
Immunoglobulin G (IgG) is a member of the immunoglobulin superfamily of glycoproteins that plays a central role in the adaptive immune response.{28520} It is produced by B cells and later secreted by plasma cells and is the most abundant circulating antibody in human and mouse serum.{28520,55170,55174} IgG consists of two heavy chains of approximately 50 kDa each and two light chains of approximately 25 kDa each.{28520} The heavy chains are linked together by disulfide bonds to form an Fc region and also combine with the light chains to form the Fab region, which mediate receptor and antigen binding, respectively.{55171} IgG exists as four isotypes in mice: IgG1, IgG2b, IgG3, and, in a strain-specific manner, IgG2a or IgG2c.{55172,53858} IgG3 production is driven by bacterial- or viral-associated antigens, including HIV-1 and Staphylococcus antigens, and occurs early in the immune response following IgM class-switching.{55170,52653} IgG3 binds to and neutralizes pathogens, as well as activates complement and opsonizes bacteria, leading to complement-dependent cytotoxicity (CDC) and antibody-dependent cell cytotoxicity (ADCC), respectively. Serum IgG3 levels are increased in patients with primary biliary cirrhosis, Sjögren's syndrome, systemic sclerosis, or systemic lupus erythematosus (SLE).{52654} Cayman's IgG3 (human) Rabbit Monoclonal Antibody - Biotinylated can be used for ELISA, immunocytochemistry (ICC), and immunohistochemistry (IHC) applications. The antibody recognizes the heavy chain of IgG3 from human samples.

Size	50 µg
Shipping	dry ice
Host	Rabbit
Antigen	Human IgG3
Clone	RM119
Isotype	IgG
Application(s)	ELISA, ICC, IHC
Formulation	50 µg of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.