ICOS/CD278 (C-Term) Rabbit Monoc

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ICOS/CD278 (C-Term) Rabbit Monoclonal Antibody

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Cat No: 32338

Inducible T cell co-stimulator (ICOS), also known as CD278, is a glycoprotein and member of the CD28/B7 family of co-stimulatory receptors that promotes T cell activation.{57036} It exists as a membrane-bound disulfide-linked homodimer and contains a ...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

CD-28 278 B-7 4 8 IL2 IL4 IL5 IL6 IL10 IFN? RM-417

Product Overview:
Inducible T cell co-stimulator (ICOS), also known as CD278, is a glycoprotein and member of the CD28/B7 family of co-stimulatory receptors that promotes T cell activation.{57036} It exists as a membrane-bound disulfide-linked homodimer and contains a leader peptide, an extracellular domain that interacts with ICOS ligand (ICOSL), and a cytoplasmic tail that mediates association with PI3K and is critical for T cell activation.{57036,57037} ICOS is expressed on activated CD4+ and CD8+ T cells following T cell receptor crosslinking and/or co-stimulation by CD28.{57036} ICOS co-stimulation of T cells induces production of IL-4, IL-5, IL-6, IFN-γ (Item Nos. 32008
32078), TNF-α (Item Nos. 32020
32069), and GM-CSF (Item Nos. 32044
32079), but not IL-2, and superinduces production of IL-10, as well as prevents T cell apoptosis.{57037} Human melanoma cells express ICOSL and promote the expansion of ICOS+ IL-10-secreting regulatory T cells, which is positively correlated with unfavorable clinical outcomes.{57039} Administration of an anti-ICOS monoclonal antibody ameliorates mucosal inflammation and damage in a mouse model of T helper cell-induced chronic colitis.{57038} Cayman’s ICOS/CD278 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) applications.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Peptide from the C-terminal region of human ICOS
Clone	RM417
Isotype	IgG
Application(s)	IHC
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.