CPS1 (N-Term) Rabbit Monoclonal

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CPS1 (N-Term) Rabbit Monoclonal Antibody

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Cat No: 32320

Carbamoyl phosphate synthetase I (CPS1) is a ligase involved in the urea cycle.{59777} It is composed of an N-terminal domain containing an ancestral inactive glutaminase, a bicarbonate phosphorylation site, and a C-terminal domain containing a carbam...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

CPS-1 CPSaseI co-factor

Product Overview:
Carbamoyl phosphate synthetase I (CPS1) is a ligase involved in the urea cycle.{59777} It is composed of an N-terminal domain containing an ancestral inactive glutaminase, a bicarbonate phosphorylation site, and a C-terminal domain containing a carbamate phosphorylation site and the binding site for the CPS1 allosteric activator N-acetyl-L-glutamate (NAG). It is primarily expressed in the liver and intestinal epithelial cells and is localized to the mitochondrial matrix.{59778,59777} CPS1, with NAG as a cofactor, catalyzes the formation of carbamoyl phosphate from ammonia, bicarbonate, and ATP as the first, rate-limiting step in the urea cycle. Mutations in CPS1 result in CPS1 deficiency, a disorder characterized by low levels of active CPS1, arginine, and citrulline and high levels of ammonia and glutamine, leading to neurological deficits and, potentially, death.{59779,59781} Protein levels of CPS1 are increased in patient-derived rectal cancer tumors and associated with shorter disease-specific survival and metastasis-free survival.{59780} Cayman’s CPS1 (N-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Peptide from the N-terminal region of CPS1
Clone	RM395
Isotype	IgG
Application(s)	IHC, WB
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.