CD8a (C-Term) Rabbit Monoclonal

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CD8a (C-Term) Rabbit Monoclonal Antibody

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Cat No: 32319

The CD8 α-chain (CD8a) is a transmembrane glycoprotein that exists as a homodimer, CD8αα, or heterodimer with the CD8 β-chain (CD8b), CD8αβ, to form the T cell receptor (TCR) co-receptor CD8.{53531,58323} CD8a is composed of an extracellular immunoglo...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

?chain ?chain coreceptor variablelike Mycobacterium Cterm

Product Overview:
The CD8 α-chain (CD8a) is a transmembrane glycoprotein that exists as a homodimer, CD8αα, or heterodimer with the CD8 β-chain (CD8b), CD8αβ, to form the T cell receptor (TCR) co-receptor CD8.{53531,58323} CD8a is composed of an extracellular immunoglobulin variable-like (IgV) domain, which interacts with MHC class I molecules, a transmembrane domain, and a cytoplasmic tail that associates with the tyrosine kinase p56Ick and mediates signal transduction.{53531,58321,58323} CD8αβ is expressed by cytotoxic T lymphocytes (CTLs), where it acts as a TCR co-receptor by enhancing T cell signaling and activation upon binding to antigen-displaying MHC class I molecules.{58322,58323} CD8αα is expressed by CTLs and intestinal epithelial lymphocytes, as well as γδ T, natural killer (NK), and dendritic cells, where it acts as a positive or negative regulator of cell activation in a cell-dependent manner. Cd8a-/- mice infected with M. tuberculosis exhibit reduced survival.{58324} Cayman's CD8a (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Peptide from the C-terminal region of human CD8
Clone	RM397
Isotype	IgG
Application(s)	IHC, WB
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.