Integrin ?3/CD61 Rabbit Monoclon

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Integrin ?3/CD61 Rabbit Monoclonal Antibody

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Cat No: 32310

Integrins are cell adhesion receptors that mediate the attachment of cells to the extracellular matrix (ECM) and facilitate cell-cell interactions.{59572} The integrin family contains 18 α subunits and eight β subunits that form 24 different heterodim...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

CD 61 ? 3

Product Overview:
Integrins are cell adhesion receptors that mediate the attachment of cells to the extracellular matrix (ECM) and facilitate cell-cell interactions.{59572} The integrin family contains 18 α subunits and eight β subunits that form 24 different heterodimers grouped into familial subgroups based on subunit composition and/or their ligand binding properties. Integrin β3, also known as CD61, is an integrin subunit that associates with αIIB or αv integrin subunits, forming αIIBβ3 and αvβ3 integrin heterodimers, respectively, which function as receptors for a variety of ECM proteins, including fibrinogen, fibronectin, and collagen and mediate outside-in and inside-out signaling cascades.{58263,58264,58265} Integrin β3 is composed of a ligand-binding extracellular domain, a single transmembrane segment, and a short cytoplasmic tail.{58264} It is expressed by platelets, megakaryocytes, and endothelial cells, as well as monocytes and macrophages. Mutations in ITGB3 have been found in patients with Glanzmann thrombasthenia, a hemorrhagic disease characterized by defects in platelet function, and ITGB3 SNPs are associated with increased risk of myocardial infarction.{58263} Cayman's Integrin β3/CD61 Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

Size	100 µL
Shipping	dry ice
Host	Rabbit
Antigen	Peptide corresponding to the internal region of human integrin ?3
Clone	RM382
Isotype	IgG
Application(s)	IHC, WB
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.