BOB-1/OBF-1 (C-Term) Rabbit Mono

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BOB-1/OBF-1 (C-Term) Rabbit Monoclonal Antibody

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Cat No: 32303

B cell Oct Binding Factor 1 (BOB-1) is a transcription factor that has a role in B cell development and function.{57410} It contains a polypeptide region, a two-turn α-helix, and a disordered region.{57411} It is primarily expressed on B cells, with t...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

BOB1 OBF1 ?helix IL4 interleukin CD-40 40L Oct1 Oct2 POU2AF Co-activator OCAB poly-peptide Anti-body

Product Overview:
B cell Oct Binding Factor 1 (BOB-1) is a transcription factor that has a role in B cell development and function.{57410} It contains a polypeptide region, a two-turn α-helix, and a disordered region.{57411} It is primarily expressed on B cells, with the highest expression in germinal center B cells, and transiently expressed on activated T cells.{57410} Its expression is induced by downstream signaling of B cell receptors, as well as IL-4, CD40 ligand (CD40L), and LPS.{57412} BOB-1 is a coactivator that is recruited to the POU domain of the transcription factors Oct-1 and Oct-2 and enhances their transactivation.{57410} Mice deficient in POU2AF1, the gene encoding BOB-1, have reduced numbers of transitional and mature B cells and lack a marginal zone B cell compartment and germinal center in the bone marrow, leading to deficits in secondary immunoglobulin isotype production.{57412,57413} POU2AF1 is downregulated in classical, but not lymphocyte-predominant, Hodgkin lymphoma.{57414} Cayman’s BOB-1/OBF-1 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Peptide from the C-terminal region of human BOB-1
Clone	RM378
Isotype	IgG
Application(s)	IHC, WB
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.