VEGF-A 164 variant (mouse, recom

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VEGF-A 164 variant (mouse, recombinant)

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Cat No: 32068

Proteins - More Proteins

VEGF-A is a member of the PDGF/VEGF family of growth factors that regulates development, proliferation, and maintenance of the vascular system.{53796} Alternative splicing of Vegfa pre-mRNA leads to the formation of VEGF-A 164 variant (VEGF-164), an i...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

VEGFA PDG-F VEGF164 VEGFR-1 2 NRP-1 2 Ala-27

Product Overview:
VEGF-A is a member of the PDGF/VEGF family of growth factors that regulates development, proliferation, and maintenance of the vascular system.{53796} Alternative splicing of Vegfa pre-mRNA leads to the formation of VEGF-A 164 variant (VEGF-164), an isoform of VEGF-A that contains two heparin binding domains that interact with VEGFR1 and VEGFR2, the VEGFR co-receptors neuropilin-1 (NRP1) and NRP2, and matrix-associated glycosaminoglycans.{53797,53798} VEGF-164 exists as a secreted or matrix-bound homodimer and is expressed in the brain, bone, eye, heart, lung, kidney and liver.{53799,53800} Transgenic overexpression of VEGF-164 in the podocytes of mice induces complete collapse of the glomerular capillary network and is perinatal lethal.{53801} Inhibition of VEGF-164 with a neutralizing aptamer inhibits leukocyte adhesion and neovascularization in the retina in a rat model of hyperoxia-induced proliferative retinopathy.{53802} Serum levels of the human homolog VEGF-165 are increased in patients with melanoma and positively correlated with metastasis.{53803} VEGF-165 levels are also increased in the serum, synovial fluid, and inflamed joints of patients with rheumatoid arthritis.{53804} Cayman's VEGF-A 164 variant (mouse, recombinant) protein can be used for cell-based assay applications. This protein consists of 164 amino acids, has a calculated molecular weight of 19.4 kDa, and a predicted N-terminus of Ala27 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the molecular weight of the protein is 24 kDa due to apparent post-translational modifications.

Size	5 µg
Shipping	dry ice
Formulation	Lyophilized from sterile 20 mM HAC-sodium acetate, pH 6.5, with 500 mM sodium chloride
Purity	≥90% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.