PDE1B1 (human, recombinant)

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Cat No: 32040

Proteins - Enzymes

Phosphodiesterase 1B (PDE1B) is a calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase that hydrolyzes both cAMP and cGMP.{56071} Alternative splicing of PDE1B pre-mRNA results in the formation of various PDE1B isoforms, including PDE1B1....

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

PDE 1B 1B1 premRNA KO R 6 R2 SDSPAGE 63 kDa CamPDE CamPDE1B PDE1B

Product Overview:
Phosphodiesterase 1B (PDE1B) is a calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase that hydrolyzes both cAMP and cGMP.{56071} Alternative splicing of PDE1B pre-mRNA results in the formation of various PDE1B isoforms, including PDE1B1.{56072} PDE1B1 is comprised of an N-terminal calmodulin binding domain, a catalytic domain, and a C-terminal domain.{56071} PDE1B1 is expressed in the brain, with the highest levels observed in the caudate nucleus and putamen.{56072} PDE1B knockout mice have decreased striatal serotonin levels and exhibit increased spontaneous locomotor activity in a novel environment, as well as increased methamphetamine-induced locomotor activity compared with wild-type mice.{56073} Striatal expression of PDE1B is decreased in the R6/2 transgenic mouse model of Huntington's disease.{56074} Cayman's PDE1B1 (human, recombinant) protein consists of 773 amino acids and has a calculated molecular weight of 89.2 kDa.

Size	50 µg
Shipping	dry ice
Formulation	Lyophilized from sterile 50 mM Tris, pH 8.0, with 100 mM sodium chloride
Purity	≥94% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.