Ganglioside GM1 (ovine) (ammoniu

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Ganglioside G_M1 (ovine) (ammonium salt)

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Cat No: 31549

Biochemicals - Lipids

Ganglioside GM1 is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.{31218,52660} It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in th...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-O-[O-?-D-galactopyranosyl-(1?3)-O-2-(acetylamino)-2-deoxy-?-D-galactopyranosyl-(1?4)-O-[N-acetyl-?-neuraminosyl-(2?3)]-O-?-D-galactopyranosyl-(1?4)-?-D-glucopyranosyl]-ceramide, monoammonium salt

Correlated keywords:

104443-62-1 37758-47-7 mono-sialylated G-M1 A1 GA GM-1 Trk-A B GFR-? FA C-18 Escherichia

Product Overview:
Ganglioside GM1 is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.{31218,52660} It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane.{53951} It associates with growth factor receptors, including TrkA, TrkB, and the GDNF receptor complex containing Ret and GFRα, and is required for TrkA expression on the cell surface. Ganglioside GM1 interacts with other proteins to increase calcium influx, affecting various calcium-dependent processes, including inducing neuronal outgrowth during differentiation. Ganglioside GM1 acts as a receptor for cholera toxin, which binds to its oligosaccharide group, facilitating toxin cell entry into epithelial cells of the jejunum.{53952,53953} Similarly, it is bound by the heat-labile enterotoxin from E. coli in the pathogenesis of traveler's diarrhea.{53954} Ganglioside GM1 sensitizes inactivated T cells to TNF-α-induced apoptosis and induces apoptosis of activated T cells even in the absence of TNF-α.{52850} Ganglioside GM1 is found at higher levels on T cells isolated from patients with renal cell carcinoma (RCC) compared with T cells from patients without cancer. Levels of ganglioside GM1 are decreased in the substantia nigra pars compacta in postmortem brain from patients with Parkinson's disease.{53951} Ganglioside GM1 gangliosidosis, characterized by a deficiency in GM1-β-galactosidase, the enzyme that degrades ganglioside GM1, leads to accumulation of the gangliosides GM1 and GA1 in neurons and can be fatal in infants.{31218} Ganglioside GM1 mixture contains ganglioside GM1 molecular species isolated from ovine brain with primarily C18:0 acyl chain lengths, among various others. [Matreya, LLC. Catalog No. 1544]

Size	5 mg
Shipping	dry ice
CAS Number	1007119-81-4
Molecular Formula	C₇₃H₁₃₀N₃O₃₁ • NH₄ (for stearoyl)
SMILES	[H][C@](CO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)O)O)CO)O[C@@]5(C([O-])=O)O[C@]([C@@H]([C@@H](CO)O)O)([H])[C@H](NC(C)=O)[C@@H](O)C5)
Molecular Weight	1563,9
Formulation	A solid
Purity	≥98%
Custom Code	2938.90
UNSPSC code	12352100

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Ganglioside GM1 (ovine) (ammonium salt)