Malotilate

Confirm delete?

Malotilate

Zoom

Cat No: 30266

Biochemicals - More Biochemicals

Malotilate is a hepatoprotective agent.{46922} It inhibits A23187-induced metabolism of arachidonic acid (Item Nos. 90010
90010.1
10006607) to the 5-lipoxygenase (5-LO) metabolites leukotriene B4 (LTB4; Item No. 20110) and 5-HETE in macrophages is...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-(1,3-dithiol-2-ylidene)-propanedioic acid, 1,3-bis(1-methylethyl) ester

Correlated keywords:

Hepation Kantec NKK105 5LO B 4 LTB 5HETE

Product Overview:
Malotilate is a hepatoprotective agent.{46922} It inhibits A23187-induced metabolism of arachidonic acid (Item Nos. 90010
90010.1
10006607) to the 5-lipoxygenase (5-LO) metabolites leukotriene B4 (LTB4; Item No. 20110) and 5-HETE in macrophages isolated from the ascitic fluid of patients with alcoholic liver cirrhosis. Malotilate (50 mg/kg) prevents increases in plasma glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase (GOT) activities in a rat model of carbon tetrachloride-induced liver injury.{46923} It reduces hepatic deposition of type III procollagen, type IV collagen, laminin, and fibronectin in a rat model of dimethylnitrosamine-induced hepatic fibrosis when administered at a dose of 100 mg/kg.{46924}

Size	1 g
Shipping	dry ice
CAS Number	59937-28-9
Molecular Formula	C₁₂H₁₆O₄S₂
SMILES	CC(C)OC(/C(C(OC(C)C)=O)=C1SC=CS\1)=O
Molecular Weight	288,4
Formulation	A solid
Purity	≥98%
Custom Code	2934.99
UNSPSC code	12352100

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.