22-NBD Cholesterol

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22-NBD Cholesterol

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Cat No: 30136

22-NBD cholesterol is a fluorescent analog of cholesterol (Item No. 9003100) that contains a fluorescent nitrobenzoxadiazole (NBD) group.{53577} It has been used in a variety of in vitro and in vivo applications, including analysis of steroid uptake a...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

20S-methyl-21-[(7-nitro-2,1,3?-benzoxadiazol-4-yl)amino]-pregn-5-en-3-ol

Correlated keywords:

Fluoresterol Fluorestrol 22NBD 22NC 22-NC nitro-benzoxadiazole

Product Overview:
22-NBD cholesterol is a fluorescent analog of cholesterol (Item No. 9003100) that contains a fluorescent nitrobenzoxadiazole (NBD) group.{53577} It has been used in a variety of in vitro and in vivo applications, including analysis of steroid uptake and esterification, intracellular localization and targeting, and metabolism in mammalian and bacterial cells, and intestinal absorption of cholesterol in hamsters.{53578,53579,53580} 22-NBD cholesterol displays excitation/emission maxima of 472/540 nm, respectively, when incorporated into 1,2-dimyristoyl-sn-glycero-3-PC (DMPC; Item No. 15097) vesicles.{53581} The emission maximum of 22-NBD cholesterol is solvent-dependent and increases as solvent polarity increases.{53577}

Size	500 µg
Shipping	dry ice
CAS Number	78949-95-8
Molecular Formula	C₂₈H₃₈N₄O₄
SMILES	C[C@H](CNC1=CC=C([N+]([O-])=O)C2=NON=C12)[C@@]3([H])CC[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@@]43C
Molecular Weight	494,6
Formulation	A solid
Purity	≥90%
Custom Code	2906.13
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.