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Wogonoside

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    Wogonoside
  • Wogonoside
Cat No: 29332
Biochemicals - Lipids
Cayman

Wogonoside is an active metabolite of wogonin (Item No. 14248) and a flavonoid that has been found in S. baicalensis and has anti-inflammatory and anticancer activities.{49413,49419,49420} It decreases the levels of IL-1β, TNF-α, and IL-6 and inhibits...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 5-hydroxy-8-methoxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl ?-D-glucopyranosiduronic acid
Correlated keywords:
  • Oroxindin glucuronopyranoside antiinflammatory anti-cancer Scutellaria IL1? TNF? IL6 NF?B NLRP-3 THP1 MDAMB231 MDAMB-231 MDA-MB231 Wnt-3a MCF7
Product Overview:
Wogonoside is an active metabolite of wogonin (Item No. 14248) and a flavonoid that has been found in S. baicalensis and has anti-inflammatory and anticancer activities.{49413,49419,49420} It decreases the levels of IL-1β, TNF-α, and IL-6 and inhibits the activation of NF-κB and the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome in THP-1 cells differentiated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).{49413} Wogonoside (25 and 50 mg/kg) decreases colonic pathological damage and the activity of myeloperoxidase and inducible nitric oxide synthase (iNOS), as well as inhibits NF-κB and NLRP3 inflammasome activation in the colon in a mouse model of colitis induced by dextran sulfate sodium (Item No. 23250). It inhibits phosphorylation of the mammalian target of rapamycin (mTOR), as well as inhibits the growth of (IC50 = 133.9 µM), and induces autophagy in, MDA-MB-231 breast cancer cells.{49419} Wogonoside (50-100 µM) inhibits tube formation by human umbilical vein endothelial cells (HUVECs) and increases Wnt3a levels and β-catenin phosphorylation in MCF-7 cells and reduces tumor growth and angiogenesis in an MCF-7 mouse xenograft model when administered at a dose of 80 mg/kg.{49420}
Size 10 mg
Shipping dry ice
CAS Number 51059-44-0
Molecular Formula C22H20O11
SMILES O=C(C1=C(O)C=C(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O2)C(OC)=C1O3)C=C3C4=CC=CC=C4
Molecular Weight 460,4
Formulation A solid
Purity ≥98%
Custom Code 2938.90
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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