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Reserpine

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    Reserpine
  • Reserpine
Cat No: 16474
Biochemicals - Natural Products
Cayman
€33.00
Price is excluding VAT and does not include packaging neither shipping

Reserpine is an alkaloid isolated from dried roots of R. serpentine, which is used in traditional Indian medicine. Reserpine irreversibly inhibits both human isoforms of vesicular monoamine transporter, VMAT1 and VMAT2 (Kis = 34 and 12 nM, respectivel...

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • (3β,16β,17α,18β,20α)-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester
Correlated keywords:
  • 1407-​38-​1 8048-​25-​7 141099-​49-​2 873409-​80-​4 natural products inhibitors neuroscience apoplon NSC 237659 NSC 59272 serpalan serpasil serpentine alkaloids inhibits VMATs VMAT-1 VMAT-2 vesicular monoamines p-glycoproteins hiserpia Rauwolfia serpentine anquil apoplon banasil bioserpine carpacil crystoserpine deserpine ENT 50146 elserpine eserpine eskaserp hiposerpil kitine lemiserp loweserp mayserpine quiescin rau-​sed raucap raulen raunervil raupasil raurine rausedyl rausingle rauwasedin resercaps resercen reserlor reserpamed reserpex reserpil reserpoid resine respital restran riserpa rivasin roxinoid sandril sedaraupin sedserp serfin serolfia serp-​AFD serpaloid serpanray serpasil serpasil serpasol serpasil premix serpasol serpate serpen serpentina serpicon serpiloid serpines serpine serpipur sertabs sertina T-​serp temposerpine triserpin vio-​serpine
Product Overview:
Reserpine is an alkaloid isolated from dried roots of R. serpentine, which is used in traditional Indian medicine. Reserpine irreversibly inhibits both human isoforms of vesicular monoamine transporter, VMAT1 and VMAT2 (Kis = 34 and 12 nM, respectively).{26972,26973} As this leads to metabolism of monoamines, reserpine is used to experimentally deplete monoamines in animals.{26970,26971,20200} Reserpine also inhibits the multidrug resistance protein P-glycoprotein (IC50 = 0.5 µM).{25345}
Size 1 g
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 50-55-5
Molecular Formula C33H40N2O9
SMILES COC1=CC(C(O[C@@H]2C[C@@](CN(CCC3=C4NC5=C3C=CC(OC)=C5)[C@]4([H])C6)([H])[C@@]6([H])[C@H](C(OC)=O)[C@H]2OC)=O)=CC(OC)=C1OC
Molecular Weight 608,7
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.49
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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