DADLE

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DADLE

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Cat No: 28928

Biochemicals - Receptor Pharmacology

DADLE is a peptide agonist of δ-opioid receptors (Ki = 2.06 nM in a radioligand binding assay).{37712} It is selective for δ-opioid over κ-opioid receptors (Ki = 16,000 nM) but also agonizes μ-opioid receptors (Ki = 13.8 nM). DADLE inhibits electrical...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-tyrosyl-D-alanylglycyl-L-phenylalanyl-D-leucine

Correlated keywords:

radio ligand cerebro DLeu5 DAla2 [D-Ala2, D-Leu5]Enkephalin BW180 BW 180 180C BW180C DADL Tyr-D-Ala-Gly-Phe-D-Leu-OH Alanine Alanine2 Leucine Leucine5 161: PN: US20030176421 PAGE: 54-55 claimed protein

Product Overview:
DADLE is a peptide agonist of δ-opioid receptors (Ki = 2.06 nM in a radioligand binding assay).{37712} It is selective for δ-opioid over κ-opioid receptors (Ki = 16,000 nM) but also agonizes μ-opioid receptors (Ki = 13.8 nM). DADLE inhibits electrically induced contractions in guinea pig myenteric plexus and mouse and rat vas deferens (IC50s = 8.9, 0.73, and 134 nM, respectively). It induces analgesia in the tail-flick and hot plate tests in mice (ED50s = 0.03 and 0.027 nmol per animal, i.c.v.).{52196} DADLE (2.5 mg/kg) decreases infarct volume in a rat model of cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{52197}

Size	1 mg
Shipping	dry ice
CAS Number	63631-40-3
Molecular Formula	C₂₉H₃₉N₅O₇
SMILES	OC1=CC=C(C[C@H](N)C(N[C@H](C)C(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@H](CC(C)C)C(O)=O)=O)=O)=O)=O)C=C1
Molecular Weight	569,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2924.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.