Permethrin

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Permethrin

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Cat No: 23821

Biochemicals - Pesticides

Permethrin is a modulator of voltage-gated sodium channels (NaV) that is used as an insecticide.{36375} It delays channel deactivation of the NaV1.8 channel expressed in X. laevis oocytes. It is at least 100-fold more potent at insect than mammalian s...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-(2,2-dichloroethenyl)-2,2-dimethyl-cyclopropanecarboxylic acid, (3-phenoxyphenyl)methyl ester

Correlated keywords:

57608-04-5 60018-94-2 63364-00-1 75497-64-2 93388-66-0 2048189-28-0 2048189-55-3 Xenopus BV2 TNF? ?-1 acticin adion ambush aninsen per-30 per30 anomethrin N antiborer-3768 antiborer3768 aqua kontrol astro bansect bematin 987 biokill butox 50 chinetrin cooper coopex corsair damminix dancide PS 150 dichlorophenothrin diffusil H dragnet FT dragon ecsumin ectiban efmethrin eliminator ant flea tick killer elimite eulan SPA everwood PC 30W exmin FMC 33297 41655 ICI-PP 557 ICIPP- 557 ICIPP557 imperator infectopedicul insectal plus insorbcid MP ipitox JF-7065 JF7065 kaleait kavil kestrel kudos last call lyclear MP-79 MP79 mitin BC NIA-33297 NIA33297 NRDC-143 NRDC143 nedax nix PP-557 PP557 perigen 500 defense W perm up permanone 40 80 90 permasect permectin II I permethrine permitrine pertrin E piredam pounce preventol HS-75 HS75 pulvex pynosect repel riapan A ridect pour on S-3151 S3151 SBP-15131 SBP15131TEC SBP1513 SBP15131-TEC sharkesuper skintex MR-III smite EC10 spartan stomoxin stomozan tanalith T timbertreat ICP5 WL-43479 WL43479 Drosophila

Product Overview:
Permethrin is a modulator of voltage-gated sodium channels (NaV) that is used as an insecticide.{36375} It delays channel deactivation of the NaV1.8 channel expressed in X. laevis oocytes. It is at least 100-fold more potent at insect than mammalian sodium channels, leading to slow deactivation of D. para/TipE, but not rat brain IIA or β1, sodium channels expressed in X. laevis oocytes when used at a concentration of 500 nM.{36376} Permethrin (5 µM) increases sodium influx in BV-2 and primary microglial cells by approximately 28 and 29%, respectively, and activates microglia.{36377} Long-term application of permethrin leads to dose- and time-dependent intracellular sodium accumulation and TNF-α release in microglia in vitro. Formulations containing permethrin have been used for the treatment of head lice and scabies infestations.

Size	100 mg
Shipping	dry ice
CAS Number	52645-53-1
Molecular Formula	C₂₁H₂₀Cl₂O₃
SMILES	O=C(C1C(C)(C)C1/C=C(Cl)/Cl)OCC2=CC(OC3=CC=CC=C3)=CC=C2
Molecular Weight	391,3
Formulation	A crystalline solid
Purity	≥95% (mixture of isomers)
Custom Code	2914.50
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.